BACKGROUND: Adiponectin, an adipocyte-secreted hormone, has insulin-sensitizing characteristics. It remains unclear whether adiponectin may influence colorectal cancer development. METHODS: To determine whether prediagnostic levels of adiponectin were associated with risk of incident colorectal cancer in the Women's Health Study, we conducted a nested case-control study of 275 colorectal cancer cases and 275 matched controls. Each case was matched to a control by age, ethnicity, fasting status at the time of blood collection, time of day when blood was drawn, and month of blood draw. Multivariable logistic regression with adjustment for colorectal cancer risk factors was used to estimate the odds ratio (OR) and 95 % confidence interval (CI) for risk of colorectal cancer incidence and mortality by adiponectin quartiles based on the control distribution. RESULTS: Median plasma adiponectin level was similar in cases versus controls (6.00 vs. 6.24 μg/mL). In multivariable-adjusted logistic regression models, high plasma adiponectin levels were not significantly associated with risk of colorectal cancer [quartile 4 (Q4) vs. quartile 1 (Q1): OR (95 % CI) 0.86 (0.48-1.56), p trend = 0.63]. CONCLUSIONS: These results suggest no appreciable association between plasma adiponectin and risk of colorectal cancer in women. Confirmation of these observations in larger studies is needed.
BACKGROUND:Adiponectin, an adipocyte-secreted hormone, has insulin-sensitizing characteristics. It remains unclear whether adiponectin may influence colorectal cancer development. METHODS: To determine whether prediagnostic levels of adiponectin were associated with risk of incident colorectal cancer in the Women's Health Study, we conducted a nested case-control study of 275 colorectal cancer cases and 275 matched controls. Each case was matched to a control by age, ethnicity, fasting status at the time of blood collection, time of day when blood was drawn, and month of blood draw. Multivariable logistic regression with adjustment for colorectal cancer risk factors was used to estimate the odds ratio (OR) and 95 % confidence interval (CI) for risk of colorectal cancer incidence and mortality by adiponectin quartiles based on the control distribution. RESULTS: Median plasma adiponectin level was similar in cases versus controls (6.00 vs. 6.24 μg/mL). In multivariable-adjusted logistic regression models, high plasma adiponectin levels were not significantly associated with risk of colorectal cancer [quartile 4 (Q4) vs. quartile 1 (Q1): OR (95 % CI) 0.86 (0.48-1.56), p trend = 0.63]. CONCLUSIONS: These results suggest no appreciable association between plasma adiponectin and risk of colorectal cancer in women. Confirmation of these observations in larger studies is needed.
Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: Esther K Wei; Edward Giovannucci; Charles S Fuchs; Walter C Willett; Christos S Mantzoros Journal: J Natl Cancer Inst Date: 2005-11-16 Impact factor: 13.506
Authors: Mingyang Song; Jian Gong; Edward L Giovannucci; Sonja I Berndt; Hermann Brenner; Jenny Chang-Claude; Keith R Curtis; Tabitha A Harrison; Michael Hoffmeister; Li Hsu; Shuo Jiao; Loic Le Marchand; John D Potter; Robert E Schoen; Daniela Seminara; Martha L Slattery; Emily White; Kana Wu; Shuji Ogino; Charles S Fuchs; David J Hunter; Shelley S Tworoger; Frank B Hu; Eric Rimm; Majken Jensen; Ulrike Peters; Andrew T Chan Journal: Int J Cancer Date: 2014-12-08 Impact factor: 7.396
Authors: Esther K Wei; Jing Ma; Michael N Pollak; Nader Rifai; Charles S Fuchs; Susan E Hankinson; Edward Giovannucci Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-04 Impact factor: 4.254
Authors: Wenjie Ma; Mingyang Song; Andrew T Chan; Edward L Giovannucci; Xuehong Zhang; Ane Sørlie Kværner; Jennifer Prescott Journal: Cancer Prev Res (Phila) Date: 2018-07-10
Authors: Tomi Akinyemiju; Justin Xavier Moore; Suzanne E Judd; Maria Pisu; Michael Goodman; Virginia J Howard; Leann Long; Monika Safford; Susan C Gilchrist; Mary Cushman Journal: Oncotarget Date: 2018-02-23
Authors: Maria Castejón; Adrian Plaza; Jorge Martinez-Romero; Pablo Jose Fernandez-Marcos; Rafael de Cabo; Alberto Diaz-Ruiz Journal: Nutrients Date: 2020-01-01 Impact factor: 5.717