Micheline Maire1,2, Carolin Franziska Reichert1,2, Virginie Gabel1,2, Antoine U Viola1,2, Christophe Phillips3, Julia Krebs1,2, Klaus Scheffler4,5, Markus Klarhöfer6, Werner Strobel7, Christian Cajochen1,2, Christina Schmidt1,2. 1. Center for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland. 2. Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland. 3. Cyclotron Research Center, Department of Electrical Engineering and Computer Science, University of Liège, Liège, Belgium. 4. MRC-Department, MPI for Biological Cybernetics, Tübingen, Germany. 5. Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany. 6. Department of Medical Radiology, MR-Physics, University of Basel, Basel, Switzerland. 7. Respiratory Medicine, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Abstract
OBJECTIVE: Even though wakefulness at night leads to profound performance deterioration and is regularly experienced by shift workers, its cerebral correlates remain virtually unexplored. METHODS: We assessed brain activity in young healthy adults during a vigilant attention task under high and low sleep pressure during night-time, coinciding with strongest circadian sleep drive. We examined sleep-loss-related attentional vulnerability by considering a PERIOD3 polymorphism presumably impacting on sleep homeostasis. RESULTS: Our results link higher sleep-loss-related attentional vulnerability to cortical and subcortical deactivation patterns during slow reaction times (i.e., suboptimal vigilant attention). Concomitantly, thalamic regions were progressively less recruited with time-on-task and functionally less connected to task-related and arousal-promoting brain regions in those volunteers showing higher attentional instability in their behavior. The data further suggest that the latter is linked to shifts into a task-inactive default-mode network in between task-relevant stimulus occurrence. INTERPRETATION: We provide a multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposition entails differential cerebral coping mechanisms, potentially compromising adequate performance during night work.
OBJECTIVE: Even though wakefulness at night leads to profound performance deterioration and is regularly experienced by shift workers, its cerebral correlates remain virtually unexplored. METHODS: We assessed brain activity in young healthy adults during a vigilant attention task under high and low sleep pressure during night-time, coinciding with strongest circadian sleep drive. We examined sleep-loss-related attentional vulnerability by considering a PERIOD3 polymorphism presumably impacting on sleep homeostasis. RESULTS: Our results link higher sleep-loss-related attentional vulnerability to cortical and subcortical deactivation patterns during slow reaction times (i.e., suboptimal vigilant attention). Concomitantly, thalamic regions were progressively less recruited with time-on-task and functionally less connected to task-related and arousal-promoting brain regions in those volunteers showing higher attentional instability in their behavior. The data further suggest that the latter is linked to shifts into a task-inactive default-mode network in between task-relevant stimulus occurrence. INTERPRETATION: We provide a multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposition entails differential cerebral coping mechanisms, potentially compromising adequate performance during night work.
Authors: Carolin F Reichert; Micheline Maire; Virginie Gabel; Antoine U Viola; Thomas Götz; Klaus Scheffler; Markus Klarhöfer; Christian Berthomier; Werner Strobel; Christophe Phillips; Eric Salmon; Christian Cajochen; Christina Schmidt Journal: Sci Rep Date: 2017-07-17 Impact factor: 4.379
Authors: Micheline Maire; Carolin F Reichert; Virginie Gabel; Antoine U Viola; Christophe Phillips; Christian Berthomier; Stefan Borgwardt; Christian Cajochen; Christina Schmidt Journal: Sci Rep Date: 2018-01-17 Impact factor: 4.379
Authors: Gina Marie Mathew; Stephen M Strayer; Kelly M Ness; Margeaux M Schade; Nicole G Nahmod; Orfeu M Buxton; Anne-Marie Chang Journal: Sci Rep Date: 2021-09-27 Impact factor: 4.379