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Literature DB >> 25938873

Dual Inhibition And Monitoring Of Beta-amyloid Fibrillation By A Luminescent Iridium(III) Complex.

Chun-Yuen Wong¹, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung, Dik-Lung Ma.

Abstract

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer's disease diagnosis and treatment.

Entities: Chemical Disease Gene

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Year: 2015 PMID： 25938873 DOI： 10.2174/1567205012666150504144558

Source DB: PubMed Journal: Curr Alzheimer Res ISSN： 1567-2050 Impact factor: 3.498

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Cited

6 in total

1. Identification of Di/Tripeptide(s) With Osteoblasts Proliferation Stimulation Abilities of Yak Bone Collagen by in silico Screening and Molecular Docking.

Authors: Yongkai Chen; Yujie Guo; Yusi Liu; Chunhui Zhang; Feng Huang; Lingyun Chen
Journal: Front Nutr Date: 2022-05-30

2. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

Authors: Michael W Beck; Jeffrey S Derrick; Jong-Min Suh; Mingeun Kim; Kyle J Korshavn; Richard A Kerr; Woo Jong Cho; Scott D Larsen; Brandon T Ruotolo; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal: ChemMedChem Date: 2017-10-09 Impact factor: 3.466

3. Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation.

Authors: Juhye Kang; Jung Seung Nam; Hyuck Jin Lee; Geewoo Nam; Hyun-Woo Rhee; Tae-Hyuk Kwon; Mi Hee Lim
Journal: Chem Sci Date: 2019-06-05 Impact factor: 9.825

Dual Inhibition And Monitoring Of Beta-amyloid Fibrillation By A Luminescent Iridium(III) Complex.

1. Identification of Di/Tripeptide(s) With Osteoblasts Proliferation Stimulation Abilities of Yak Bone Collagen by in silico Screening and Molecular Docking.

2. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

3. Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation.

4. Excited-State Intramolecular Hydrogen Transfer of Compact Molecules Controls Amyloid Aggregation Profiles.

5. Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity.

6. Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes.