Sheng Zhang1, Weifeng Tang1, Guowen Ding1, Chao Liu1, Ruiping Liu1, Suocheng Chen1, Haiyong Gu1, Chunzhao Yu1. 1. 1 Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China ; 2 Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, China ; 3 Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
Abstract
OBJECTIVE: To investigate the association between gastric cardia adenocarcinoma (GCA) and ten functional single nucleotide polymorphisms (SNPs), including TP53BP1 rs560191 G>C, CASP8 rs1035142 G>T, CASP7 rs3127075 G>C, CASP7 rs7907519 C>A, and six C1orf10/CRNN variants. We performed a hospital-based case-control study to evaluate the genetic effects of these SNPs. METHODS: Two hundred and forty-three GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscan(TM) Kit was used to determine their genotypes. RESULTS: When the TP53BP1 rs560191 GG homozygote genotype was used as the reference group, the GC genotype was associated with a significantly increased risk of GCA. The CC genotype was not associated with the risk of GCA compared with the GG genotype. None of the CASP8 rs1035142 G>T, CASP7 rs3127075 G>C, CASP7 rs7907519 C>A or the six C1orf10/CRNN polymorphisms showed a significant difference in genotype distributions between the cases and the controls. CONCLUSIONS: The results demonstrated that the functional polymorphism TP53BP1 rs560191 G>C might contribute to GCA susceptibility. However, the statistical power of our study was limited. Large, well-designed studies and further functional investigations are needed to confirm our findings.
OBJECTIVE: To investigate the association between gastric cardia adenocarcinoma (GCA) and ten functional single nucleotide polymorphisms (SNPs), including TP53BP1rs560191 G>C, CASP8rs1035142 G>T, CASP7rs3127075 G>C, CASP7rs7907519 C>A, and six C1orf10/CRNN variants. We performed a hospital-based case-control study to evaluate the genetic effects of these SNPs. METHODS: Two hundred and forty-three GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscan(TM) Kit was used to determine their genotypes. RESULTS: When the TP53BP1rs560191 GG homozygote genotype was used as the reference group, the GC genotype was associated with a significantly increased risk of GCA. The CC genotype was not associated with the risk of GCA compared with the GG genotype. None of the CASP8rs1035142 G>T, CASP7rs3127075 G>C, CASP7rs7907519 C>A or the six C1orf10/CRNN polymorphisms showed a significant difference in genotype distributions between the cases and the controls. CONCLUSIONS: The results demonstrated that the functional polymorphism TP53BP1rs560191 G>C might contribute to GCA susceptibility. However, the statistical power of our study was limited. Large, well-designed studies and further functional investigations are needed to confirm our findings.
Authors: Bernd Frank; Kari Hemminki; Justo Lorenzo Bermejo; Rüdiger Klaes; Peter Bugert; Barbara Wappenschmidt; Rita K Schmutzler; Barbara Burwinkel Journal: Breast Cancer Res Date: 2005-05-06 Impact factor: 6.466