Haibo Zhang1, Shanhu Hao2, Junhua Zhao3, Baosen Zhou4, Yangwu Ren4, Ying Yan5, Yuxia Zhao6. 1. Department of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, Shenyang, PR China; Department of Radiation Oncology, the General Hospital of Shenyang Military Region, Shenyang, PR China. 2. Department of Nuclear Medicine, the General Hospital of Shenyang Military Region, Shenyang, PR China. 3. Department of the Seven Year Clinics, China Medical University, Shenyang, PR China. 4. Department of Epidemiology, School of Public Health, China Medical University, Shenyang, PR China. 5. Department of Radiation Oncology, the General Hospital of Shenyang Military Region, Shenyang, PR China. 6. Department of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, Shenyang, PR China. Electronic address: zyx_yd@163.com.
Abstract
BACKGROUND AND AIMS: The study investigated several common SNPs in the tumor protein p53 binding protein 1 gene and tumor protein p53 gene in 640 lung cancer cases and 685 controls in Han Chinese to determine if these single nucleotide polymorphisms (SNPs) were associated with lung cancer risk. Several studies indicated that SNPs in the 53BP1 and TP53 gene are associated with cancer risk. We investigated the association between common SNP variants in the 53BP1, TP53 gene and lung cancer risk. METHODS: We used real-time PCR method to investigate the genotypic frequencies of rs2602141, rs560191 and rs689647 in 53BP1 and rs1042522 in TP53 in 640 cases of lung cancer and 685 controls. RESULTS: SNPs rs2602141, rs560191 and rs689647 in 53BP1 were in complete linkage disequilibrium in Han Chinese. The frequencies of the G/G, G/T and T/T genotypes of rs2602141 were 17.5, 50.3 and 32.2% in cases and 21.0, 49.3 and 29.6% in controls, respectively and distributions were not significantly different (p = 0.236). The rs2602141 T/T genotype increased NSCLC risk (OR = 1.56, 95% CI = 1.10-2.21). CONCLUSIONS: The genotype distribution frequency of rs1042522 does not demonstrate significant differences between cases and control group. 53BP1 and TP53 gene interactions were not associated with lung cancer risk.
BACKGROUND AND AIMS: The study investigated several common SNPs in the tumor protein p53 binding protein 1 gene and tumor protein p53 gene in 640 lung cancer cases and 685 controls in Han Chinese to determine if these single nucleotide polymorphisms (SNPs) were associated with lung cancer risk. Several studies indicated that SNPs in the 53BP1 and TP53 gene are associated with cancer risk. We investigated the association between common SNP variants in the 53BP1, TP53 gene and lung cancer risk. METHODS: We used real-time PCR method to investigate the genotypic frequencies of rs2602141, rs560191 and rs689647 in 53BP1 and rs1042522 in TP53 in 640 cases of lung cancer and 685 controls. RESULTS: SNPs rs2602141, rs560191 and rs689647 in 53BP1 were in complete linkage disequilibrium in Han Chinese. The frequencies of the G/G, G/T and T/T genotypes of rs2602141 were 17.5, 50.3 and 32.2% in cases and 21.0, 49.3 and 29.6% in controls, respectively and distributions were not significantly different (p = 0.236). The rs2602141 T/T genotype increased NSCLC risk (OR = 1.56, 95% CI = 1.10-2.21). CONCLUSIONS: The genotype distribution frequency of rs1042522 does not demonstrate significant differences between cases and control group. 53BP1 and TP53 gene interactions were not associated with lung cancer risk.