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Literature DB >> 25937135

No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.

Abstract

Cochlear ribbon synapses are required for the rapid and precise neural transmission of acoustic signals from inner hair cells to the spiral ganglion neurons. Emerging evidence suggests that damage to these synapses represents an important form of cochlear neuropathy that might be highly prevalent in sensorineural hearing loss. In this review, we discuss our current knowledge on how ribbon synapses are damaged by noise and during aging, as well as potential strategies to promote ribbon synapse regeneration for hearing restoration.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Glutamic Acid

Year: 2015 PMID： 25937135 PMCID： PMC4624482 DOI： 10.1016/j.heares.2015.04.008

Source DB: PubMed Journal: Hear Res ISSN： 0378-5955 Impact factor: 3.208

189 in total

1. Quantitative evaluation of the human cochlear nerve.

Authors: H Spoendlin; A Schrott
Journal: Acta Otolaryngol Suppl Date: 1990

Review 2. Dynamic aspects of CNS synapse formation.

Authors: A Kimberley McAllister
Journal: Annu Rev Neurosci Date: 2007 Impact factor: 12.449

3. Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti.

Authors: A Matsubara; J H Laake; S Davanger; S Usami; O P Ottersen
Journal: J Neurosci Date: 1996-07-15 Impact factor: 6.167

Review 4. Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis.

Authors: Marlies Knipper; Pim Van Dijk; Isidro Nunes; Lukas Rüttiger; Ulrike Zimmermann
Journal: Prog Neurobiol Date: 2013-09-06 Impact factor: 11.685

Review 8. Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.

Authors: Gaëlle Naert; Marie-Pierre Pasdelou; Colleen G Le Prell
Journal: J Acoust Soc Am Date: 2019-11 Impact factor: 2.482

Review 9. Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish.

Authors: Katie S Kindt; Lavinia Sheets
Journal: Front Cell Dev Biol Date: 2018-09-11

9 in total

No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.

1. Quantitative evaluation of the human cochlear nerve.

Review 2. Dynamic aspects of CNS synapse formation.

3. Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti.

Review 4. Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis.

5. Contribution of auditory nerve fibers to compound action potential of the auditory nerve.

6. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.

7. Hair cell loss in the aged guinea pig cochlea.

8. Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain.

9. Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury.

10. Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling.

Review 1. Neuroprotective role of insulin-like growth factor 1 in auditory and other nervous systems.

2. Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice.

Review 3. Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms.

4. Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.

Review 5. The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss.

6. Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice.

Review 7. Pathology and mechanisms of cochlear aging.

Review 8. Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.

Review 9. Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish.