I Ozbay1, C Kahraman2, H H Balikci3, C Kucur1, N K Kahraman2, D P Ozkaya2, F Oghan1. 1. Department of Otorhinolaryngology,Dumlupınar University,Kutahya. 2. Department of Internal Medicine,Dumlupınar University Evliya Celebi Education and Research Hospital,Kutahya. 3. Department of Otorhinolaryngology,Susehri State Hospital,Sivas,Turkey.
Abstract
OBJECTIVE: To determine the relationship between severe tinnitus and inflammation using the neutrophil-to-lymphocyte ratio as a marker of stress. METHODS: A total of 107 patients who had been suffering with severe tinnitus (tinnitus handicap inventory scale grades of 3-5) for at least 2 weeks were recruited. Patients underwent detailed ENT examinations and audiometric tests to exclude a relevant pathological cause of the tinnitus. Patients with systemic diseases, malignancy or inflammatory diseases that could alter neutrophil-to-lymphocyte ratio were excluded. A total of 107 age- and sex-matched healthy control participants were also recruited. Routine laboratory test results and neutrophil-to-lymphocyte ratio were compared between the patients and controls. RESULTS: Lipid profile, liver function, white blood cell count, haemoglobin level, mean corpuscular volume, and vitamin B12 and folate levels were similar among the patients and controls. However, mean neutrophil-to-lymphocyte ratio was significantly higher among the patients than the controls (p < 0.05). CONCLUSION: The findings of this novel study suggest that neutrophil-to-lymphocyte ratio should be considered during the evaluation of tinnitus patients as a potential clinical marker of tinnitus. Further studies are required to verify the findings.
OBJECTIVE: To determine the relationship between severe tinnitus and inflammation using the neutrophil-to-lymphocyte ratio as a marker of stress. METHODS: A total of 107 patients who had been suffering with severe tinnitus (tinnitus handicap inventory scale grades of 3-5) for at least 2 weeks were recruited. Patients underwent detailed ENT examinations and audiometric tests to exclude a relevant pathological cause of the tinnitus. Patients with systemic diseases, malignancy or inflammatory diseases that could alter neutrophil-to-lymphocyte ratio were excluded. A total of 107 age- and sex-matched healthy control participants were also recruited. Routine laboratory test results and neutrophil-to-lymphocyte ratio were compared between the patients and controls. RESULTS:Lipid profile, liver function, white blood cell count, haemoglobin level, mean corpuscular volume, and vitamin B12 and folate levels were similar among the patients and controls. However, mean neutrophil-to-lymphocyte ratio was significantly higher among the patients than the controls (p < 0.05). CONCLUSION: The findings of this novel study suggest that neutrophil-to-lymphocyte ratio should be considered during the evaluation of tinnituspatients as a potential clinical marker of tinnitus. Further studies are required to verify the findings.
Authors: Yasin Sarıkaya; Cem Bayraktar; Mehmet Karataş; Sedat Doğan; Serdar Olt; Emin Kaskalan; İbrahim Halil Türkbeyler Journal: Eur Arch Otorhinolaryngol Date: 2016-02-22 Impact factor: 2.503
Authors: Laura Basso; Benjamin Boecking; Patrick Neff; Petra Brueggemann; Linda El-Ahmad; Jelena Brasanac; Matthias Rose; Stefan M Gold; Birgit Mazurek Journal: Front Psychol Date: 2022-06-23