Petar Milovanovic1, Umaimatu Adamu2, Maciej J K Simon2, Tim Rolvien2, Marija Djuric3, Michael Amling2, Björn Busse4. 1. Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Germany. Laboratory for Anthropology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Serbia. 2. Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Germany. 3. Laboratory for Anthropology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Serbia. 4. Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Germany. b.busse@uke.uni-hamburg.de.
Abstract
BACKGROUND: Age- and sex-specific 3D bone structure patterns in human radii and tibiae were investigated with respect to individuals' osteodensitometric status to unravel associations with site-specific fracture occurrences and underlying loading patterns. METHODS: A sample of 385 patients (121 men and 264 women, age range: 23-91 years) were investigated. The patients were classified according to dual X-ray absorptiometry T-scores in three groups: control (n = 60), osteopenia (n = 160), and osteoporosis (n = 165). Bone architecture and geometry were assessed by high-resolution peripheral quantitative computed tomography of the cortical and trabecular compartments in distal radii and tibiae. RESULTS: We found site-dependent age- and sex-related trends regarding bone architecture and geometry. Females displayed more pronounced age-related changes than males. Specifically, female radii showed both cortical and trabecular structural deterioration with aging, whereas the tibiae demonstrated exclusively cortical deterioration. The mean cortical perimeter revealed a significant age-related increase for both sexes even after adjusting for body height and weight, which suggests that periosteal expansion can be observed in both the tibia and also in the radius. Osteopenia and osteoporosis cases did not reveal higher cortical perimeters in comparison to controls. CONCLUSIONS: The tomographic assessment of bone structure further clarifies the architectural basis for increased bone fragility at distal radii and tibiae with advanced age leading to fracture predilection in females. Our findings may represent a morphological link to epidemiological data on age-dependent fracture incidences. Our data support the presence of periosteal apposition at both skeletal sites despite different loading magnitudes, and challenges the view on periosteal expansion just as a compensatory mechanism to counterbalance bone loss.
BACKGROUND: Age- and sex-specific 3D bone structure patterns in human radii and tibiae were investigated with respect to individuals' osteodensitometric status to unravel associations with site-specific fracture occurrences and underlying loading patterns. METHODS: A sample of 385 patients (121 men and 264 women, age range: 23-91 years) were investigated. The patients were classified according to dual X-ray absorptiometry T-scores in three groups: control (n = 60), osteopenia (n = 160), and osteoporosis (n = 165). Bone architecture and geometry were assessed by high-resolution peripheral quantitative computed tomography of the cortical and trabecular compartments in distal radii and tibiae. RESULTS: We found site-dependent age- and sex-related trends regarding bone architecture and geometry. Females displayed more pronounced age-related changes than males. Specifically, female radii showed both cortical and trabecular structural deterioration with aging, whereas the tibiae demonstrated exclusively cortical deterioration. The mean cortical perimeter revealed a significant age-related increase for both sexes even after adjusting for body height and weight, which suggests that periosteal expansion can be observed in both the tibia and also in the radius. Osteopenia and osteoporosis cases did not reveal higher cortical perimeters in comparison to controls. CONCLUSIONS: The tomographic assessment of bone structure further clarifies the architectural basis for increased bone fragility at distal radii and tibiae with advanced age leading to fracture predilection in females. Our findings may represent a morphological link to epidemiological data on age-dependent fracture incidences. Our data support the presence of periosteal apposition at both skeletal sites despite different loading magnitudes, and challenges the view on periosteal expansion just as a compensatory mechanism to counterbalance bone loss.
Authors: S Butscheidt; A Delsmann; T Rolvien; F Barvencik; M Al-Bughaili; S Mundlos; T Schinke; M Amling; U Kornak; R Oheim Journal: Osteoporos Int Date: 2018-03-29 Impact factor: 4.507
Authors: D E Whittier; S K Boyd; A J Burghardt; J Paccou; A Ghasem-Zadeh; R Chapurlat; K Engelke; M L Bouxsein Journal: Osteoporos Int Date: 2020-05-26 Impact factor: 4.507
Authors: Petar Milovanovic; Zorica Vukovic; Djordje Antonijevic; Danijela Djonic; Vladimir Zivkovic; Slobodan Nikolic; Marija Djuric Journal: J Mater Sci Mater Med Date: 2017-03-29 Impact factor: 3.896
Authors: Amy Creecy; Sasidhar Uppuganti; Madeline R Girard; Siegfried G Schlunk; Chidi Amah; Mathilde Granke; Mustafa Unal; Mark D Does; Jeffry S Nyman Journal: Bone Date: 2019-10-31 Impact factor: 4.398
Authors: Elizabeth A Zimmermann; Eric Schaible; Bernd Gludovatz; Felix N Schmidt; Christoph Riedel; Matthias Krause; Eik Vettorazzi; Claire Acevedo; Michael Hahn; Klaus Püschel; Simon Tang; Michael Amling; Robert O Ritchie; Björn Busse Journal: Sci Rep Date: 2016-02-16 Impact factor: 4.379
Authors: Sanne Treurniet; Elisabeth M W Eekhoff; Felix N Schmidt; Dimitra Micha; Björn Busse; Nathalie Bravenboer Journal: Front Endocrinol (Lausanne) Date: 2020-06-23 Impact factor: 5.555