Lucy McGeoch1, Simon Carette1, David Cuthbertson1, Gary S Hoffman1, Nader Khalidi1, Curry L Koening1, Carol A Langford1, Carol A McAlear1, Larry Moreland1, Paul A Monach1, Philip Seo1, Ulrich Specks1, Steven R Ytterberg1, Peter A Merkel1, Christian Pagnoux. 1. From the Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada; Health Informatics Institute, University of South Florida, Tampa, Florida; Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, Ohio, USA; Division of Rheumatology, McMaster University, Hamilton, Ontario, Canada; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Division of Rheumatology, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pennsylvania; The Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland; Division of Pulmonary and Critical Care Medicine, and the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.L. McGeoch, MD; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; D. Cuthbertson, MS, Health Informatics Institute, University of South Florida; G.S. Hoffman, MD, Center for Vasculitis Care and Research, Cleveland Clinic; N. Khalidi, MD, Division of Rheumatology, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Center for Vasculitis Care and Research, Cleveland Clinic; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; P.A. Monach, MD, PhD, The Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine; P. Seo, MD, Division of Rheumatology, Johns Hopkins University; U. Specks, MD, Division of Pulmonary and Critical Care Medicine; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital.
Abstract
OBJECTIVE: To determine frequency and outcomes of granulomatosis with polyangiitis (GPA)-related cardiac disease in a North American GPA cohort. METHODS: Analysis was done of all patients in the Vasculitis Clinical Research Consortium Longitudinal Study of GPA. Demographic and clinical characteristics of patients with and without GPA-related cardiac involvement were compared. RESULTS: Of 517 patients with GPA, 3.3% had cardiac involvement. No differences were observed between patients with or without cardiac involvement in terms of demographics, antineutrophil cytoplasmic antibody positivity, or relapse rate. CONCLUSION: Cardiac involvement in GPA is rare and heterogeneous. In this cohort, cardiac involvement was not associated with a higher rate of relapse or premature death.
OBJECTIVE: To determine frequency and outcomes of granulomatosis with polyangiitis (GPA)-related cardiac disease in a North American GPA cohort. METHODS: Analysis was done of all patients in the Vasculitis Clinical Research Consortium Longitudinal Study of GPA. Demographic and clinical characteristics of patients with and without GPA-related cardiac involvement were compared. RESULTS: Of 517 patients with GPA, 3.3% had cardiac involvement. No differences were observed between patients with or without cardiac involvement in terms of demographics, antineutrophil cytoplasmic antibody positivity, or relapse rate. CONCLUSION:Cardiac involvement in GPA is rare and heterogeneous. In this cohort, cardiac involvement was not associated with a higher rate of relapse or premature death.
Entities:
Keywords:
CARDIAC DISEASE; GRANULOMATOSIS WITH POLYANGIITIS; VASCULITIS
Authors: R Y Leavitt; A S Fauci; D A Bloch; B A Michel; G G Hunder; W P Arend; L H Calabrese; J F Fries; J T Lie; R W Lightfoot Journal: Arthritis Rheum Date: 1990-08
Authors: Michael Walsh; Oliver Flossmann; Annelies Berden; Kerstin Westman; Peter Höglund; Coen Stegeman; David Jayne Journal: Arthritis Rheum Date: 2012-02
Authors: Matthew D Morgan; Jennifer Turnbull; Umut Selamet; Manvir Kaur-Hayer; Peter Nightingale; Charles J Ferro; Caroline O S Savage; Lorraine Harper Journal: Arthritis Rheum Date: 2009-11
Authors: Loïc Guillevin; Christian Pagnoux; Raphaele Seror; Alfred Mahr; Luc Mouthon; Philippe Le Toumelin Journal: Medicine (Baltimore) Date: 2011-01 Impact factor: 1.889
Authors: S Morelli; A M Gurgo Di Castelmenardo; F Conti; A Sgreccia; C Alessandri; M L Bernardo; G Valesini Journal: Rheumatol Int Date: 2000 Impact factor: 2.631
Authors: Julia U Holle; Christin Dubrau; Karen Herlyn; Martin Heller; Petra Ambrosch; Bernhard Noelle; Eva Reinhold-Keller; Wolfgang L Gross Journal: Ann Rheum Dis Date: 2011-10-21 Impact factor: 19.103
Authors: Tomasz Miszalski-Jamka; Wojciech Szczeklik; Barbara Sokołowska; Karol Miszalski-Jamka; Krzysztof Karwat; Gabriel Grządziel; Wojciech Mazur; Dean J Kereiakes; Jacek Musiał Journal: Eur Radiol Date: 2011-07-23 Impact factor: 5.315
Authors: Laryssa Passos Sarmento Santos; Victor Guerreiro Bomfim; Camila Fagundes Bezerra; Natália Vieira Costa; Rafael Barreto Paes de Carvalho; Ricardo Sobral de Carvalho; Rogério da Hora Passos; Olivia Carla Bomfim Boaventura; André Luiz Nunes Gobatto Journal: Rev Bras Ter Intensiva Date: 2017 Jul-Sep
Authors: Marie Chevenon; Nicholas Robles; Sydney Elizer; Erik Ellsworth; Stephen Pophal; Arash Sabati Journal: Pediatr Cardiol Date: 2022-04-09 Impact factor: 1.838