| Literature DB >> 25934486 |
Abhiram Pushparaj1, Aaron S Kim1, Martin Musiol1, Jose M Trigo1, Bernard Le Foll2.
Abstract
Our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. Recent studies in various animal models of addiction for nicotine and other drugs have identified a role for the rostral agranular subregion (RAIC). The current research was undertaken to examine the involvement of the RAIC in a rat model of nicotine self-administration. We investigated the inactivating effects of local infusions of a γ-aminobutyric acid agonist mixture (baclofen/muscimol) into the RAIC on nicotine self-administration under a fixed-ratio 5 (FR-5) schedule and on reinstatement of nicotine seeking induced by nicotine-associated cues in rats. We also evaluated the effects of RAIC inactivation on food self-administration under an FR5 schedule as a control. Inactivation of the RAIC decreased nicotine, but not food, self-administration. RAIC inactivation also prevented the reinstatement, after extinction, of nicotine seeking induced by nicotine-associated cues. Our study indicates that the RAIC is involved in nicotine-taking and nicotine-seeking in rats. Modulating insular cortex function appears to be a promising approach for nicotine dependence treatment.Entities:
Keywords: Nicotine; Rat; Reinstatement; Rostral agranular insular cortex; Self-administration
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Year: 2015 PMID： 25934486 DOI： 10.1016/j.bbr.2015.04.039
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332