Literature DB >> 25934337

Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer.

Li Liu1,2, Yuchen Liu1, Chengle Zhuang1,2, Wen Xu3, Xing Fu1, Zhaojie Lv1, Hanwei Wu1, Lisha Mou1, Guoping Zhao1,4, Zhiming Cai5,6, Weiren Huang7.   

Abstract

Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play important roles in cancer development and progression. Prostate cancer-associated transcript 1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer. We hypothesized that PCAT-1 also have roles in bladder cancer. In this study, we found that PCAT-1 was up-regulated in bladder cancer compared to paired normal urothelium. Cell proliferation inhibition and apoptosis induction were also observed in PCAT-1 small hairpin RNA (shRNA)-transfected bladder cancer T24 and 5637 cells. Our data suggest that PCAT-1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer.

Entities:  

Keywords:  Apoptosis; Bladder cancer; PCAT-1; Proliferation

Mesh：

Substances：

Year:  2015        PMID： 25934337     DOI： 10.1007/s13277-015-3490-3

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  10 in total

Review 1.  Biomarkers in bladder cancer: translational and clinical implications.

Authors:  Liang Cheng; Darrell D Davison; Julia Adams; Antonio Lopez-Beltran; Lisha Wang; Rodolfo Montironi; Shaobo Zhang
Journal:  Crit Rev Oncol Hematol       Date:  2013-08-29       Impact factor: 6.312

Review 2.  Long non-coding RNAs: a new frontier in the study of human diseases.

Authors:  Xuefei Shi; Ming Sun; Hongbing Liu; Yanwen Yao; Yong Song
Journal:  Cancer Lett       Date:  2013-06-18       Impact factor: 8.679

Review 3.  Decoding the function of nuclear long non-coding RNAs.

Authors:  Ling-Ling Chen; Gordon G Carmichael
Journal:  Curr Opin Cell Biol       Date:  2010-03-29       Impact factor: 8.382

4.  Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer.

Authors:  Xiaosong Ge; Yuanbin Chen; Xiaoyu Liao; Deqing Liu; Fangfang Li; Honglian Ruan; Weihua Jia
Journal:  Med Oncol       Date:  2013-05-03       Impact factor: 3.064

Review 5.  Bladder cancer.

Authors:  Donald S Kaufman; William U Shipley; Adam S Feldman
Journal:  Lancet       Date:  2009-06-10       Impact factor: 79.321

6.  Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression.

Authors:  John R Prensner; Matthew K Iyer; O Alejandro Balbin; Saravana M Dhanasekaran; Qi Cao; J Chad Brenner; Bharathi Laxman; Irfan A Asangani; Catherine S Grasso; Hal D Kominsky; Xuhong Cao; Xiaojun Jing; Xiaoju Wang; Javed Siddiqui; John T Wei; Daniel Robinson; Hari K Iyer; Nallasivam Palanisamy; Christopher A Maher; Arul M Chinnaiyan
Journal:  Nat Biotechnol       Date:  2011-07-31       Impact factor: 54.908

7.  The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.

Authors:  John R Prensner; Matthew K Iyer; Anirban Sahu; Irfan A Asangani; Qi Cao; Lalit Patel; Ismael A Vergara; Elai Davicioni; Nicholas Erho; Mercedeh Ghadessi; Robert B Jenkins; Timothy J Triche; Rohit Malik; Rachel Bedenis; Natalie McGregor; Teng Ma; Wei Chen; Sumin Han; Xiaojun Jing; Xuhong Cao; Xiaoju Wang; Benjamin Chandler; Wei Yan; Javed Siddiqui; Lakshmi P Kunju; Saravana M Dhanasekaran; Kenneth J Pienta; Felix Y Feng; Arul M Chinnaiyan
Journal:  Nat Genet       Date:  2013-09-29       Impact factor: 38.330

8.  The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc.

Authors:  John R Prensner; Wei Chen; Sumin Han; Matthew K Iyer; Qi Cao; Vishal Kothari; Joseph R Evans; Karen E Knudsen; Michelle T Paulsen; Mats Ljungman; Theodore S Lawrence; Arul M Chinnaiyan; Felix Y Feng
Journal:  Neoplasia       Date:  2014-11-20       Impact factor: 5.715

9.  PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.

Authors:  John R Prensner; Wei Chen; Matthew K Iyer; Qi Cao; Teng Ma; Sumin Han; Anirban Sahu; Rohit Malik; Kari Wilder-Romans; Nora Navone; Christopher J Logothetis; John C Araujo; Louis L Pisters; Ashutosh K Tewari; Christine E Canman; Karen E Knudsen; Naoki Kitabayashi; Mark A Rubin; Francesca Demichelis; Theodore S Lawrence; Arul M Chinnaiyan; Felix Y Feng
Journal:  Cancer Res       Date:  2014-01-28       Impact factor: 12.701

10.  The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage.

Authors:  Orit Feldstein; Tal Nizri; Tirza Doniger; Jasmine Jacob; Gideon Rechavi; Doron Ginsberg
Journal:  Mol Cancer       Date:  2013-10-29       Impact factor: 27.401
  10 in total
  27 in total

1.  Identification of long noncoding RNAs as potential novel diagnosis and prognosis biomarkers in colorectal cancer.

Authors:  Rui Wang; Lutao Du; Xiaoyun Yang; Xiumei Jiang; Weili Duan; Suzhen Yan; Yujiao Xie; Yuntao Zhu; Qingliang Wang; Lili Wang; Yongmei Yang; Chuanxin Wang
Journal:  J Cancer Res Clin Oncol       Date:  2016-09-03       Impact factor: 4.553

Review 2.  Long Noncoding RNAs as Innovative Urinary Diagnostic Biomarkers.

Authors:  Giulia Brisotto; Roberto Guerrieri; Francesca Colizzi; Agostino Steffan; Barbara Montico; Elisabetta Fratta
Journal:  Methods Mol Biol       Date:  2021

Review 3.  Long non-coding RNA in prostate cancer.

Authors:  Christine An; Ian Wang; Xin Li; Rong Xia; Fangming Deng
Journal:  Am J Clin Exp Urol       Date:  2022-06-15

4.  Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in non-small cell lung cancer cells.

Authors:  Bing Zhao; Xiabao Hou; Hui Zhan
Journal:  Int J Clin Exp Med       Date:  2015-10-15

5.  The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma.

Authors:  Yanli Ren; Jinhua Shang; Jinliang Li; Wenjuan Liu; Zhao Zhang; Jupeng Yuan; Ming Yang
Journal:  J Biol Chem       Date:  2017-09-08       Impact factor: 5.157

6.  The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma.

Authors:  Xuedong Zhang; Yakui Zhang; Yong Mao; Xinlong Ma
Journal:  Onco Targets Ther       Date:  2018-01-31       Impact factor: 4.147

7.  Increased expression of SUMO1P3 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer.

Authors:  Yonghao Zhan; Yuchen Liu; Chaoliang Wang; Junhao Lin; Mingwei Chen; Xiaoying Chen; Chengle Zhuang; Li Liu; Wen Xu; Qing Zhou; Xiaojuan Sun; Qiaoxia Zhang; Guoping Zhao; Weiren Huang
Journal:  Oncotarget       Date:  2016-03-29

8.  Inhibiting cell migration and cell invasion by silencing the transcription factor ETS-1 in human bladder cancer.

Authors:  Li Liu; Yuchen Liu; Xintao Zhang; Mingwei Chen; Hanwei Wu; Muqi Lin; Yonghao Zhan; Chengle Zhuang; Junhao Lin; Jianfa Li; Wen Xu; Xing Fu; Qiaoxia Zhang; Xiaojuan Sun; Guoping Zhao; Weiren Huang
Journal:  Oncotarget       Date:  2016-05-03

Review 9.  Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation.

Authors:  Jiajia Chen; Zhijun Miao; Boxin Xue; Yuxi Shan; Guobin Weng; Bairong Shen
Journal:  J Cancer       Date:  2016-08-15       Impact factor: 4.207

10.  The prognostic potential and carcinogenesis of long non-coding RNA TUG1 in human cholangiocarcinoma.

Authors:  Yi Xu; Kaiming Leng; Zhenglong Li; Fumin Zhang; Xiangyu Zhong; Pengcheng Kang; Xingming Jiang; Yunfu Cui
Journal:  Oncotarget       Date:  2017-07-22
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