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Literature DB >> 25934179

Dynamic structures in DNA damage responses & cancer.

John A Tainer¹.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：
DNA, Neoplasm

Year: 2015 PMID： 25934179 PMCID： PMC5080980 DOI： 10.1016/j.pbiomolbio.2015.04.003

Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667

× No keyword cloud information.

62 in total

Review 1. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.

Authors: Gareth J Williams; Susan P Lees-Miller; John A Tainer
Journal: DNA Repair (Amst) Date: 2010-10-28

2. Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.

Authors: V A Roberts; H C Freeman; A J Olson; J A Tainer; E D Getzoff
Journal: J Biol Chem Date: 1991-07-15 Impact factor: 5.157

Review 3. The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.

Authors: Kenichi Hitomi; Shigenori Iwai; John A Tainer
Journal: DNA Repair (Amst) Date: 2007-01-08

4. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.

Authors: Jillian Orans; Elizabeth A McSweeney; Ravi R Iyer; Michael A Hast; Homme W Hellinga; Paul Modrich; Lorena S Beese
Journal: Cell Date: 2011-04-15 Impact factor: 41.582

Review 5. The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.

Authors: Susan E Tsutakawa; Julien Lafrance-Vanasse; John A Tainer
Journal: DNA Repair (Amst) Date: 2014-04-19

6. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.

Authors: S P Lees-Miller; C W Anderson
Journal: J Biol Chem Date: 1989-10-15 Impact factor: 5.157

7. Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.

Authors: Hikmat Al-Ahmadie; Gopa Iyer; Marcel Hohl; Saurabh Asthana; Akiko Inagaki; Nikolaus Schultz; Aphrothiti J Hanrahan; Sasinya N Scott; A Rose Brannon; Gregory C McDermott; Mono Pirun; Irina Ostrovnaya; Philip Kim; Nicholas D Socci; Agnes Viale; Gary K Schwartz; Victor Reuter; Bernard H Bochner; Jonathan E Rosenberg; Dean F Bajorin; Michael F Berger; John H J Petrini; David B Solit; Barry S Taylor
Journal: Cancer Discov Date: 2014-06-16 Impact factor: 39.397

Dynamic structures in DNA damage responses & cancer.

Review 1. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.

2. Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.

Review 3. The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.

4. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.

Review 5. The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.

6. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.

7. Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.

8. Structure of the DNA repair helicase XPD.

9. DNA ligases as therapeutic targets.

Review 10. Therapeutic opportunities within the DNA damage response.

1. Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions.