Literature DB >> 25933186

Incidence of Epstein-Barr virus in Syrian women with breast cancer: A tissue microarray study.

Tahar Aboulkassim1, Amber Yasmeen, Nizar Akil, Gerald Batist, Ala-Eddin Al Moustafa.   

Abstract

Epstein-Barr virus (EBV) has been recently shown to be present in human breast cancer worldwide, which could play an important role in the initiation and progression of this cancer. In this regard, we aimed to explore the prevalence of EBV in 108 breast cancer tissues from Syrian women using polymerase chain reaction (PCR) and tissue microarray (TMA) analysis. We found that EBV is present in 56 (51.85%) of breast cancers samples. Additionally, we report that the expression of LMP1 gene of EBV is associated with a cancer invasive phenotype in the majority of the cancer samples. These data imply that EBV is present in breast cancer worldwide including Syria and its presence is associated with more aggressive cancer phenotype. Thus, future investigations are needed to elucidate the exact role of EBV in breast carcinogenesis and metastasis.

Entities:  

Keywords:  Epstein–Barr virus; Syrian women; breast cancer; invasive cancer

Mesh：

Substances：

Year:  2015        PMID： 25933186      PMCID： PMC4514243          DOI： 10.1080/21645515.2015.1009342

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  28 in total

Review 1.  Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders.

Authors:  Jaap M Middeldorp; Antoinette A T P Brink; Adriaan J C van den Brule; Chris J L M Meijer
Journal:  Crit Rev Oncol Hematol       Date:  2003-01       Impact factor: 6.312

Review 2.  The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).

Authors:  Christopher W Dawson; Rebecca J Port; Lawrence S Young
Journal:  Semin Cancer Biol       Date:  2012-01-12       Impact factor: 15.707

3.  Investigation of Epstein-Barr virus DNA in formalin-fixed and paraffin- embedded breast cancer tissues.

Authors:  Ahmet Kalkan; Aykut Ozdarendeli; Yasemin Bulut; Hayrettin Yekeler; Bengu Cobanoglu; Mehmet Z Doymaz
Journal:  Med Princ Pract       Date:  2005 Jul-Aug       Impact factor: 1.927

Review 4.  Epstein-Barr virus and cancer.

Authors:  Matthew P Thompson; Razelle Kurzrock
Journal:  Clin Cancer Res       Date:  2004-02-01       Impact factor: 12.531

5.  Epstein-Barr virus and breast cancer: epidemiological and molecular study on Egyptian and Iraqi women.

Authors:  Abdel-Rahman N Zekri; Abeer A Bahnassy; Waleed S Mohamed; Fatma A El-Kassem; Saja J El-Khalidi; Mohamed M Hafez; Zeinab K Hassan
Journal:  J Egypt Natl Canc Inst       Date:  2012-07-10

6.  Identification of Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) target proteins by proteome analysis: activation of EBNA2 in conditionally immortalized B cells reflects early events after infection of primary B cells by EBV.

Authors:  Martin Schlee; Tanja Krug; Olivier Gires; Reinhard Zeidler; Wolfgang Hammerschmidt; Reinhard Mailhammer; Gerhard Laux; Guido Sauer; Josip Lovric; Georg W Bornkamm
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

7.  Detection of Epstein-Barr virus in breast carcinoma in Egyptian women.

Authors:  Shereen Fawzy; Maha Sallam; Nahla Mohammad Awad
Journal:  Clin Biochem       Date:  2008-01-03       Impact factor: 3.281

8.  Epstein-Barr virus, human papillomavirus and mouse mammary tumour virus as multiple viruses in breast cancer.

Authors:  Wendy K Glenn; Benjamin Heng; Warick Delprado; Barry Iacopetta; Noel J Whitaker; James S Lawson
Journal:  PLoS One       Date:  2012-11-19       Impact factor: 3.240

9.  High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study.

Authors:  N Akil; A Yasmeen; A Kassab; L Ghabreau; A D Darnel; A-E Al Moustafa
Journal:  Br J Cancer       Date:  2008-07-22       Impact factor: 7.640

10.  Epstein-Barr virus gene expression in human breast cancer: protagonist or passenger?

Authors:  S A Xue; I A Lampert; J S Haldane; J E Bridger; B E Griffin
Journal:  Br J Cancer       Date:  2003-07-07       Impact factor: 7.640
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  13 in total

1.  Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer.

Authors:  Ala-Eddin Al Moustafa; Noor Al-Antary; Tahar Aboulkassim; Nizar Akil; Gerald Batist; Amber Yasmeen
Journal:  Hum Vaccin Immunother       Date:  2016-04-15       Impact factor: 3.452

2.  Epstein-Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study.

Authors:  Noor Al-Antary; Hanan Farghaly; Tahar Aboulkassim; Amber Yasmeen; Nizar Akil; Ala-Eddin Al Moustafa
Journal:  Hum Vaccin Immunother       Date:  2017-03-28       Impact factor: 3.452

3.  Co-presence of human papillomaviruses and Epstein-Barr virus is linked with advanced tumor stage: a tissue microarray study in head and neck cancer patients.

Authors:  Hamda Al-Thawadi; Ishita Gupta; Ayesha Jabeen; Faruk Skenderi; Tahar Aboulkassim; Amber Yasmeen; Mohammed I Malki; Gerald Batist; Semir Vranic; Ala-Eddin Al Moustafa
Journal:  Cancer Cell Int       Date:  2020-08-03       Impact factor: 5.722

4.  Co-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women.

Authors:  Hamda Al-Thawadi; Lina Ghabreau; Tahar Aboulkassim; Amber Yasmeen; Semir Vranic; Gerald Batist; Ala-Eddin Al Moustafa
Journal:  Front Oncol       Date:  2018-07-02       Impact factor: 6.244

5.  The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer.

Authors:  Ishita Gupta; Ayesha Jabeen; Reem Al-Sarraf; Hanan Farghaly; Semir Vranic; Ali A Sultan; Ala-Eddin Al Moustafa; Hamda Al-Thawadi
Journal:  Hum Vaccin Immunother       Date:  2020-10-02       Impact factor: 3.452

6.  Co-presence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples.

Authors:  Mohammed I Malki; Ishita Gupta; Queenie Fernandes; Tahar Aboulkassim; Amber Yasmeen; Semir Vranic; Ala-Eddin Al Moustafa; Hamda A Al-Thawadi
Journal:  Hum Vaccin Immunother       Date:  2020-03-18       Impact factor: 3.452

Review 7.  Epstein-Barr Virus in Gliomas: Cause, Association, or Artifact?

Authors:  Saghir Akhtar; Semir Vranic; Farhan Sachal Cyprian; Ala-Eddin Al Moustafa
Journal:  Front Oncol       Date:  2018-04-20       Impact factor: 6.244

8.  High-risk human papillomaviruses and Epstein-Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study.

Authors:  Karim Nagi; Ishita Gupta; Nawaf Jurdi; Ayesha Jabeen; Amber Yasmeen; Gerald Batist; Semir Vranic; Ala-Eddin Al-Moustafa
Journal:  Cancer Cell Int       Date:  2021-06-10       Impact factor: 5.722

Review 9.  Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.

Authors:  Farhan S Cyprian; Halema F Al-Farsi; Semir Vranic; Saghir Akhtar; Ala-Eddin Al Moustafa
Journal:  Front Oncol       Date:  2018-05-01       Impact factor: 6.244

10.  Presence of HPV, EBV and HMTV Viruses Among Egyptian Breast Cancer Women: Molecular Detection and Clinical Relevance.

Authors:  Shimaa A Metwally; Maha A Abo-Shadi; Nasra F Abdel Fattah; Ahmed B Barakat; Omar A Rabee; Ahmed M Osman; Amany M Helal; Tarek Hashem; Manar M Moneer; Wassim Chehadeh; Samah A Loutfy
Journal:  Infect Drug Resist       Date:  2021-06-23       Impact factor: 4.003
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