OBJECTIVE: To retrospectively analyze and compare the ultrasonographic characteristics and BI-RADS-US classification between patients with BRCA1 mutation-associated breast cancer and those without BRCA1 gene mutation in Guangxi, China. METHODS: The study was performed in 36 lesions from 34 BRCA1 mutation-associated breast cancer patients. A total of 422 lesions from 422 breast cancer patients without BRCA1 mutations served as control group. The comparison of the ultrasonographic features and BI-RADS-US classification between two the groups were reviewed. RESULTS: More complex inner echo was disclosed in BRCA1 mutation-associated breast cancer patients (x(2) = 4.741, P = 0.029). The BI-RADS classification of BRCA1 mutation-associated breast cancer was lower (U = 6094.0, P = 0.022). CONCLUSIONS: BRCA1 mutation-associated breast cancer frequently displays as microlobulated margin and complex echo. It also shows more benign characteristics in morphology, and the BI-RADS classification is prone to be underestimated.
OBJECTIVE: To retrospectively analyze and compare the ultrasonographic characteristics and BI-RADS-US classification between patients with BRCA1 mutation-associated breast cancer and those without BRCA1 gene mutation in Guangxi, China. METHODS: The study was performed in 36 lesions from 34 BRCA1 mutation-associated breast cancerpatients. A total of 422 lesions from 422 breast cancerpatients without BRCA1 mutations served as control group. The comparison of the ultrasonographic features and BI-RADS-US classification between two the groups were reviewed. RESULTS: More complex inner echo was disclosed in BRCA1 mutation-associated breast cancerpatients (x(2) = 4.741, P = 0.029). The BI-RADS classification of BRCA1 mutation-associated breast cancer was lower (U = 6094.0, P = 0.022). CONCLUSIONS:BRCA1 mutation-associated breast cancer frequently displays as microlobulated margin and complex echo. It also shows more benign characteristics in morphology, and the BI-RADS classification is prone to be underestimated.
Entities:
Keywords:
BRCA1 gene; Breast cancer; elastography; mutations; ultrasonography
Authors: T V Bartolotta; R Ienzi; A Cirino; C Genova; F Ienzi; D Pitarresi; E Safina; M Midiri Journal: Radiol Med Date: 2011-03-07 Impact factor: 3.469
Authors: Richard G Barr; Stamatia Destounis; Logan B Lackey; William E Svensson; Corinne Balleyguier; Carmel Smith Journal: J Ultrasound Med Date: 2012-02 Impact factor: 2.153
Authors: L J Hamilton; A J Evans; A R M Wilson; N Scott; E J Cornford; S E Pinder; H N Khan; R D Macmillan Journal: Clin Radiol Date: 2004-10 Impact factor: 2.350
Authors: Petrina A Causer; Roberta A Jong; Ellen Warner; Kimberley Hill; John W Wong; Belinda N Curpen; Donald B Plewes Journal: Radiographics Date: 2007-10 Impact factor: 5.333