Vijay Dhawan1, William Robeson2, David Bjelke3, Thomas Chaly3, Kristin Graf3, Matthew Hellman3, Limei Zhuo3, Meggan Mackay4, David Eidelberg3. 1. Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York dhawan@nshs.edu. 2. Department of Radiology, North Shore-LIJ Health System, Manhasset, New York; and. 3. Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York. 4. Center for Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, New York.
Abstract
UNLABELLED: (11)C-CNS5161 (N-(2-chloro-5-methylthiophenyl)-N'-(3-methylthiophenyl)-N'-(11)C-methylguanidine) has been successfully used in PET imaging of N-methyl-d-aspartate (NMDA) receptors. However, no human dosimetry data have been published. We are planning to use this radiotracer for investigating NMDA receptor function in systemic lupus erythematosus, traumatic brain injury, and Parkinson disease. We have therefore undertaken (11)C-CNS5161 PET imaging to measure the whole-body distribution of this radionuclide and to estimate radiation dose to various organs. METHODS: Dynamic PET studies of the whole body were performed on 5 healthy adults. Regions of interest were drawn over the visualized structures. Resultant time-activity curves were generated and used to determine residence times for dosimetry calculations. S factors were implemented within the OLINDA/EXM software for each structure or organ. RESULTS: For (11)C-CNS5161, organ doses ranged from 0.0002 to 0.0393 mGy/MBq (0.0006-0.1455 rad/mCi). The critical organ for radiation burden was the lungs, with a dose of 0.0393 mGy/MBq (0.1455 rad/mCi). Radiation doses to the reproductive and blood-forming organs were 0.0023, 0.0002, and 0.0020 mGy/MBq (0.0086, 0.0006, and 0.0074 rad/mCi) for the ovaries, testes, and red marrow, respectively. The effective dose equivalent was 0.0106 mSv/MBq (0.0392 rem/mCi). CONCLUSION: The radiation dosimetry for (11)C-CNS5161 for a standard single injection of 555 MBq (15 mCi) will result in an effective dose equivalent of 5.9 mSv (0.59 rem) and a lung dose of 21.8 mGy (2.18 rad) in young, healthy subjects.
UNLABELLED: (11)C-CNS5161 (N-(2-chloro-5-methylthiophenyl)-N'-(3-methylthiophenyl)-N'-(11)C-methylguanidine) has been successfully used in PET imaging of N-methyl-d-aspartate (NMDA) receptors. However, no human dosimetry data have been published. We are planning to use this radiotracer for investigating NMDA receptor function in systemic lupus erythematosus, traumatic brain injury, and Parkinson disease. We have therefore undertaken (11)C-CNS5161 PET imaging to measure the whole-body distribution of this radionuclide and to estimate radiation dose to various organs. METHODS: Dynamic PET studies of the whole body were performed on 5 healthy adults. Regions of interest were drawn over the visualized structures. Resultant time-activity curves were generated and used to determine residence times for dosimetry calculations. S factors were implemented within the OLINDA/EXM software for each structure or organ. RESULTS: For (11)C-CNS5161, organ doses ranged from 0.0002 to 0.0393 mGy/MBq (0.0006-0.1455 rad/mCi). The critical organ for radiation burden was the lungs, with a dose of 0.0393 mGy/MBq (0.1455 rad/mCi). Radiation doses to the reproductive and blood-forming organs were 0.0023, 0.0002, and 0.0020 mGy/MBq (0.0086, 0.0006, and 0.0074 rad/mCi) for the ovaries, testes, and red marrow, respectively. The effective dose equivalent was 0.0106 mSv/MBq (0.0392 rem/mCi). CONCLUSION: The radiation dosimetry for (11)C-CNS5161 for a standard single injection of 555 MBq (15 mCi) will result in an effective dose equivalent of 5.9 mSv (0.59 rem) and a lung dose of 21.8 mGy (2.18 rad) in young, healthy subjects.
Authors: Noora M Scheinin; Tuula K Tolvanen; Ian A Wilson; Eveliina M Arponen; Kjell A Någren; Juha O Rinne Journal: J Nucl Med Date: 2007-01 Impact factor: 10.057
Authors: D J Brooks; V Ibanez; G V Sawle; E D Playford; N Quinn; C J Mathias; A J Lees; C D Marsden; R Bannister; R S Frackowiak Journal: Ann Neurol Date: 1992-02 Impact factor: 10.422
Authors: Jasper van der Aart; William A Hallett; Eugenii A Rabiner; Jan Passchier; Robert A Comley Journal: Nucl Med Biol Date: 2011-10-26 Impact factor: 2.408
Authors: William Robeson; Vijay Dhawan; Abdel Belakhlef; Yilong Ma; Von Pillai; Thomas Chaly; Claude Margouleff; David Bjelke; David Eidelberg Journal: J Nucl Med Date: 2003-06 Impact factor: 10.057
Authors: Colm J McGinnity; Alexander Hammers; Daniela A Riaño Barros; Sajinder K Luthra; Paul A Jones; William Trigg; Caroline Micallef; Mark R Symms; David J Brooks; Matthias J Koepp; John S Duncan Journal: J Nucl Med Date: 2014-02-13 Impact factor: 10.057