Literature DB >> 25926698

A mechanism for cell motility by active polar gels.

W Marth1, S Praetorius1, A Voigt2.   

Abstract

We analyse a generic motility model, with the motility mechanism arising by contractile stress due to the interaction of myosin and actin. A hydrodynamic active polar gel theory is used to model the cytoplasm of a cell and is combined with a Helfrich-type model to account for membrane properties. The overall model allows consideration of the motility without the necessity for local adhesion. Besides a detailed numerical approach together with convergence studies for the highly nonlinear free boundary problem, we also compare the induced flow field of the motile cell with that of classical squirmer models and identify the motile cell as a puller or pusher, depending on the strength of the myosin-actin interactions.
© 2015 The Author(s) Published by the Royal Society. All rights reserved.

Entities:  

Keywords:  Helfrich model; active polar gel; cell motility; spontaneous symmetry breaking; swimmer

Mesh:

Substances:

Year:  2015        PMID: 25926698      PMCID: PMC4590500          DOI: 10.1098/rsif.2015.0161

Source DB:  PubMed          Journal:  J R Soc Interface        ISSN: 1742-5662            Impact factor:   4.118


  22 in total

1.  Asters, vortices, and rotating spirals in active gels of polar filaments.

Authors:  K Kruse; J F Joanny; F Jülicher; J Prost; K Sekimoto
Journal:  Phys Rev Lett       Date:  2004-02-20       Impact factor: 9.161

2.  Model for self-polarization and motility of keratocyte fragments.

Authors:  Falko Ziebert; Sumanth Swaminathan; Igor S Aranson
Journal:  J R Soc Interface       Date:  2011-10-19       Impact factor: 4.118

3.  Signaling networks and cell motility: a computational approach using a phase field description.

Authors:  Wieland Marth; Axel Voigt
Journal:  J Math Biol       Date:  2013-07-09       Impact factor: 2.259

4.  Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel.

Authors:  Renaud Poincloux; Olivier Collin; Floria Lizárraga; Maryse Romao; Marcel Debray; Matthieu Piel; Philippe Chavrier
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-18       Impact factor: 11.205

5.  Spontaneous division and motility in active nematic droplets.

Authors:  Luca Giomi; Antonio DeSimone
Journal:  Phys Rev Lett       Date:  2014-04-10       Impact factor: 9.161

6.  Direct measurement of the flow field around swimming microorganisms.

Authors:  Knut Drescher; Raymond E Goldstein; Nicolas Michel; Marco Polin; Idan Tuval
Journal:  Phys Rev Lett       Date:  2010-10-11       Impact factor: 9.161

7.  Computational model for cell morphodynamics.

Authors:  Danying Shao; Wouter-Jan Rappel; Herbert Levine
Journal:  Phys Rev Lett       Date:  2010-09-02       Impact factor: 9.161

8.  Effects of adhesion dynamics and substrate compliance on the shape and motility of crawling cells.

Authors:  Falko Ziebert; Igor S Aranson
Journal:  PLoS One       Date:  2013-05-31       Impact factor: 3.240

Review 9.  A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.

Authors:  Alexandra Jilkine; Leah Edelstein-Keshet
Journal:  PLoS Comput Biol       Date:  2011-04-28       Impact factor: 4.475

10.  Collisions of deformable cells lead to collective migration.

Authors:  Jakob Löber; Falko Ziebert; Igor S Aranson
Journal:  Sci Rep       Date:  2015-03-17       Impact factor: 4.379

View more
  2 in total

1.  Collective migration under hydrodynamic interactions: a computational approach.

Authors:  W Marth; A Voigt
Journal:  Interface Focus       Date:  2016-10-06       Impact factor: 3.906

2.  Deformable active nematic particles and emerging edge currents in circular confinements.

Authors:  Veit Krause; Axel Voigt
Journal:  Eur Phys J E Soft Matter       Date:  2022-02-17       Impact factor: 1.890

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.