Literature DB >> 25926650

Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer.

Peter S Lee1, Xueyong Zhu2, Wenli Yu2, Ian A Wilson3.   

Abstract

We engineered a disulfide-stabilized influenza virus hemagglutinin (HA) trimer, termed HA3-SS, by introducing cysteine residues into the HA stem to covalently bridge the three protomers. HA3-SS has increased thermostability compared to wild-type HA, and binding of head- and stem-targeted antibodies (Abs) is preserved; only minor structural changes are found in the vicinity of the additional disulfide. This platform has been applied to H1 and H3 HAs and provides prospects for design of intact, stabilized influenza virus HA immunogens.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25926650      PMCID： PMC4473583          DOI： 10.1128/JVI.00808-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

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3.  Reversible inhibition of the fusion activity of measles virus F protein by an engineered intersubunit disulfide bridge.

Authors:  Jin K Lee; Andrew Prussia; James P Snyder; Richard K Plemper
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4.  Structural characterization of an early fusion intermediate of influenza virus hemagglutinin.

Authors:  Rui Xu; Ian A Wilson
Journal:  J Virol       Date:  2011-03-02       Impact factor: 5.103

Review 5.  Broadly neutralizing antiviral antibodies.

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7.  Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.

Authors:  I A Wilson; J J Skehel; D C Wiley
Journal:  Nature       Date:  1981-01-29       Impact factor: 49.962

8.  Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin.

Authors:  Hua Yang; Paul Carney; James Stevens
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9.  Structure of influenza haemagglutinin at the pH of membrane fusion.

Authors:  P A Bullough; F M Hughson; J J Skehel; D C Wiley
Journal:  Nature       Date:  1994-09-01       Impact factor: 49.962

Review 10.  Influenza virus hemagglutinin stalk-based antibodies and vaccines.

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Journal:  Curr Opin Virol       Date:  2013-08-24       Impact factor: 7.090
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  8 in total

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Journal:  Nat Med       Date:  2022-02-03       Impact factor: 53.440

3.  New Vaccine Design and Delivery Technologies.

Authors:  Masaru Kanekiyo; Daniel Ellis; Neil P King
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4.  Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism.

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Journal:  Adv Funct Mater       Date:  2018-06-25       Impact factor: 18.808

5.  Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions.

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6.  Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH.

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Review 7.  Structure-Based and Rational Design of a Hepatitis C Virus Vaccine.

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8.  Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization.

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  8 in total

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