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Literature DB >> 25926635

Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations.

Alan M Elder, Davin M Henderson, Amy V Nalls, Edward A Hoover, Anthony E Kincaid, Jason C Bartz, Candace K Mathiason.

Abstract

Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPCCCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.

Entities: Disease Species

Mesh：

Substances：
Prions

Year: 2015 PMID： 25926635 PMCID： PMC4473550 DOI： 10.1128/JVI.00760-15

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Presymptomatic detection of prions in blood.

Authors: Paula Saá; Joaquín Castilla; Claudio Soto
Journal: Science Date: 2006-07-07 Impact factor: 47.728

2. Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep.

Authors: M Jeffrey; L González; A Espenes; C McL Press; S Martin; M Chaplin; L Davis; T Landsverk; C MacAldowie; S Eaton; G McGovern
Journal: J Pathol Date: 2006-05 Impact factor: 7.996

3. B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease.

Authors: Candace K Mathiason; Jeanette Hayes-Klug; Sheila A Hays; Jenny Powers; David A Osborn; Sallie J Dahmes; Karl V Miller; Robert J Warren; Gary L Mason; Glenn C Telling; Alan J Young; Edward A Hoover
Journal: J Virol Date: 2010-03-10 Impact factor: 5.103

4. Infectious prions in the saliva and blood of deer with chronic wasting disease.

Authors: Candace K Mathiason; Jenny G Powers; Sallie J Dahmes; David A Osborn; Karl V Miller; Robert J Warren; Gary L Mason; Sheila A Hays; Jeanette Hayes-Klug; Davis M Seelig; Margaret A Wild; Lisa L Wolfe; Terry R Spraker; Michael W Miller; Christina J Sigurdson; Glenn C Telling; Edward A Hoover
Journal: Science Date: 2006-10-06 Impact factor: 47.728

5. Transmission of prion diseases by blood transfusion.

Authors: Nora Hunter; James Foster; Angela Chong; Sandra McCutcheon; David Parnham; Samantha Eaton; Calum MacKenzie; Fiona Houston
Journal: J Gen Virol Date: 2002-11 Impact factor: 3.891

6. Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

Authors: Jason M Wilham; Christina D Orrú; Richard A Bessen; Ryuichiro Atarashi; Kazunori Sano; Brent Race; Kimberly D Meade-White; Lara M Taubner; Andrew Timmes; Byron Caughey
Journal: PLoS Pathog Date: 2010-12-02 Impact factor: 6.823

7. Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein.

Authors: Christina D Orrú; Jason M Wilham; Andrew G Hughson; Lynne D Raymond; Kristin L McNally; Alex Bossers; Ciriaco Ligios; Byron Caughey
Journal: Protein Eng Des Sel Date: 2009-07-01 Impact factor: 1.650

8. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient.

Authors: Alexander H Peden; Mark W Head; Diane L Ritchie; Jeanne E Bell; James W Ironside
Journal: Lancet Date: 2004 Aug 7-13 Impact factor: 79.321

9. Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion.

Authors: Davin M Henderson; Kristen A Davenport; Nicholas J Haley; Nathaniel D Denkers; Candace K Mathiason; Edward A Hoover
Journal: J Gen Virol Date: 2014-10-10 Impact factor: 3.891

10. Preclinical detection of variant CJD and BSE prions in blood.

Authors: Caroline Lacroux; Emmanuel Comoy; Mohammed Moudjou; Armand Perret-Liaudet; Séverine Lugan; Claire Litaise; Hugh Simmons; Christelle Jas-Duval; Isabelle Lantier; Vincent Béringue; Martin Groschup; Guillaume Fichet; Pierrette Costes; Nathalie Streichenberger; Frederic Lantier; Jean Philippe Deslys; Didier Vilette; Olivier Andréoletti
Journal: PLoS Pathog Date: 2014-06-12 Impact factor: 6.823

24 in total

1. Enhanced prion detection in biological samples by magnetic particle extraction and real-time quaking-induced conversion.

Authors: Nathaniel D Denkers; Davin M Henderson; Candace K Mathiason; Edward A Hoover
Journal: J Gen Virol Date: 2016-05-27 Impact factor: 3.891

Review 2. Prion Strain Diversity.

Authors: Jason C Bartz
Journal: Cold Spring Harb Perspect Med Date: 2016-12-01 Impact factor: 6.915

3. Using White-tailed Deer (Odocoileus virginianus) in Infectious Disease Research.

Authors: Mitchell V Palmer; Rebecca J Cox; W Ray Waters; Tyler C Thacker; Diana L Whipple
Journal: J Am Assoc Lab Anim Sci Date: 2017-07-01 Impact factor: 1.232

4. Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice.

Authors: A E Kincaid; J I Ayers; J C Bartz
Journal: J Virol Date: 2016-08-26 Impact factor: 5.103

10. Prions efficiently cross the intestinal barrier after oral administration: Study of the bioavailability, and cellular and tissue distribution in vivo.

Authors: Akihiko Urayama; Luis Concha-Marambio; Uffaf Khan; Javiera Bravo-Alegria; Vineetkumar Kharat; Claudio Soto
Journal: Sci Rep Date: 2016-08-30 Impact factor: 4.379