| Literature DB >> 17023660 |
Candace K Mathiason1, Jenny G Powers, Sallie J Dahmes, David A Osborn, Karl V Miller, Robert J Warren, Gary L Mason, Sheila A Hays, Jeanette Hayes-Klug, Davis M Seelig, Margaret A Wild, Lisa L Wolfe, Terry R Spraker, Michael W Miller, Christina J Sigurdson, Glenn C Telling, Edward A Hoover.
Abstract
A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-naïve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transfusion). The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections.Entities:
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Year: 2006 PMID： 17023660 DOI： 10.1126/science.1132661
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728