Literature DB >> 25920893

Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction.

Bin Wang1, Jinwei Ren, Liyuan Li, Fang Guo, Guohui Pan, Guomin Ai, Bertrand Aigle, Keqiang Fan, Keqian Yang.   

Abstract

The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.

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Year:  2015        PMID： 25920893     DOI： 10.1039/c5cc01986a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

Review 1.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

2.  Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis.

Authors:  Bin Wang; Fang Guo; Jinwei Ren; Guomin Ai; Bertrand Aigle; Keqiang Fan; Keqian Yang
Journal:  Nat Commun       Date:  2015-07-02       Impact factor: 14.919

Review 3.  New insights into bacterial type II polyketide biosynthesis.

Authors:  Zhuan Zhang; Hai-Xue Pan; Gong-Li Tang
Journal:  F1000Res       Date:  2017-02-21

4.  Fluostatins M-Q Featuring a 6-5-6-6 Ring Skeleton and High Oxidized A-Rings from Marine Streptomyces sp. PKU-MA00045.

Authors:  Jing Jin; Xiaoyan Yang; Tan Liu; Hua Xiao; Guiyang Wang; Mengjie Zhou; Fawang Liu; Yingtao Zhang; Dong Liu; Minghua Chen; Wei Cheng; Donghui Yang; Ming Ma
Journal:  Mar Drugs       Date:  2018-03-09       Impact factor: 5.118

5.  Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines.

Authors:  Chunshuai Huang; Chunfang Yang; Wenjun Zhang; Liping Zhang; Bidhan Chandra De; Yiguang Zhu; Xiaodong Jiang; Chunyan Fang; Qingbo Zhang; Cheng-Shan Yuan; Hung-Wen Liu; Changsheng Zhang
Journal:  Nat Commun       Date:  2018-05-25       Impact factor: 14.919

Review 6.  Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases.

Authors:  Jia Wang; Ruihua Zhang; Xin Chen; Xinxiao Sun; Yajun Yan; Xiaolin Shen; Qipeng Yuan
Journal:  Microb Cell Fact       Date:  2020-05-24       Impact factor: 5.328

Review 7.  The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines.

Authors:  Keqiang Fan; Qian Zhang
Journal:  Synth Syst Biotechnol       Date:  2018-11-14

8.  Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation.

Authors:  Chunfang Yang; Liping Zhang; Wenjun Zhang; Chunshuai Huang; Yiguang Zhu; Xiaodong Jiang; Wei Liu; Mengran Zhao; Bidhan Chandra De; Changsheng Zhang
Journal:  Nat Commun       Date:  2022-09-14       Impact factor: 17.694

9.  Unraveling the iterative type I polyketide synthases hidden in Streptomyces.

Authors:  Bin Wang; Fang Guo; Chunshuai Huang; Huimin Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-26       Impact factor: 11.205

10.  Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis.

Authors:  Kangmin Hua; Xiangyang Liu; Yuchun Zhao; Yaojie Gao; Lifeng Pan; Haoran Zhang; Zixin Deng; Ming Jiang
Journal:  mBio       Date:  2020-09-15       Impact factor: 7.867
  10 in total

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