Literature DB >> 25920610

Therapeutic potential of cancer stem cells.

Chunguang Yang1, Kunlin Jin, Yangping Tong, William Chi Cho.   

Abstract

Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer's relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.

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Year:  2015        PMID： 25920610     DOI： 10.1007/s12032-015-0619-6

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  100 in total

1.  Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.

Authors:  Yohei Shimono; Maider Zabala; Robert W Cho; Neethan Lobo; Piero Dalerba; Dalong Qian; Maximilian Diehn; Huiping Liu; Sarita P Panula; Eric Chiao; Frederick M Dirbas; George Somlo; Renee A Reijo Pera; Kaiqin Lao; Michael F Clarke
Journal:  Cell       Date:  2009-08-07       Impact factor: 41.582

Review 2.  Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.

Authors:  Thomas Brabletz; Andreas Jung; Simone Spaderna; Falk Hlubek; Thomas Kirchner
Journal:  Nat Rev Cancer       Date:  2005-09       Impact factor: 60.716

Review 3.  Wnt/beta-catenin signaling in cancer stemness and malignant behavior.

Authors:  Riccardo Fodde; Thomas Brabletz
Journal:  Curr Opin Cell Biol       Date:  2007-02-16       Impact factor: 8.382

4.  Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents.

Authors:  Rama Adikrisna; Shinji Tanaka; Shunsuke Muramatsu; Arihiro Aihara; Daisuke Ban; Takanori Ochiai; Takumi Irie; Atsushi Kudo; Noriaki Nakamura; Shoji Yamaoka; Shigeki Arii
Journal:  Gastroenterology       Date:  2012-04-14       Impact factor: 22.682

5.  Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution.

Authors:  Philippe Metellus; Isabelle Nanni-Metellus; Christine Delfino; Carole Colin; Aurelie Tchogandjian; Bema Coulibaly; Frederic Fina; Anderson Loundou; Marylin Barrie; Olivier Chinot; L'houcine Ouafik; Dominique Figarella-Branger
Journal:  Ann Surg Oncol       Date:  2011-04-09       Impact factor: 5.344

6.  Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.

Authors:  Salvatore Pece; Daniela Tosoni; Stefano Confalonieri; Giovanni Mazzarol; Manuela Vecchi; Simona Ronzoni; Loris Bernard; Giuseppe Viale; Pier Giuseppe Pelicci; Pier Paolo Di Fiore
Journal:  Cell       Date:  2010-01-08       Impact factor: 41.582

7.  Identification of pancreatic cancer stem cells.

Authors:  Chenwei Li; David G Heidt; Piero Dalerba; Charles F Burant; Lanjing Zhang; Volkan Adsay; Max Wicha; Michael F Clarke; Diane M Simeone
Journal:  Cancer Res       Date:  2007-02-01       Impact factor: 12.701

8.  Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells.

Authors:  Z Liu; Q Li; K Li; L Chen; W Li; M Hou; T Liu; J Yang; C Lindvall; M Björkholm; J Jia; D Xu
Journal:  Oncogene       Date:  2012-10-08       Impact factor: 9.867

9.  Notch receptor activation inhibits oligodendrocyte differentiation.

Authors:  S Wang; A D Sdrulla; G diSibio; G Bush; D Nofziger; C Hicks; G Weinmaster; B A Barres
Journal:  Neuron       Date:  1998-07       Impact factor: 17.173

10.  The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer.

Authors:  X B Trinh; W A A Tjalma; P B Vermeulen; G Van den Eynden; I Van der Auwera; S J Van Laere; J Helleman; E M J J Berns; L Y Dirix; P A van Dam
Journal:  Br J Cancer       Date:  2009-02-24       Impact factor: 7.640
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  8 in total

1.  Imaging Early Fate of Cancer Stem Cells in Mouse Hindlimbs with Sodium Iodide Symporter Gene and I-124 PET.

Authors:  Jin Won Park; Kyung-Ho Jung; Jin Hee Lee; Seung Hwan Moon; Young Seok Cho; Yearn Seung Choe; Kyung-Han Lee
Journal:  Mol Imaging Biol       Date:  2016-10       Impact factor: 3.488

2.  TGFβ2 is a Prognostic Biomarker for Gastric Cancer and is Associated With Methylation and Immunotherapy Responses.

Authors:  Bangling Han; Tianyi Fang; Yimin Wang; Yongle Zhang; Yingwei Xue
Journal:  Front Genet       Date:  2022-05-10       Impact factor: 4.772

Review 3.  Transglutaminase is a tumor cell and cancer stem cell survival factor.

Authors:  Richard L Eckert; Matthew L Fisher; Dan Grun; Gautam Adhikary; Wen Xu; Candace Kerr
Journal:  Mol Carcinog       Date:  2015-08-10       Impact factor: 4.784

4.  GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway.

Authors:  Yan-Liang Li; Joseph T Chang; Li-Yu Lee; Kang-Hsing Fan; Ya-Ching Lu; Yi-Chen Li; Chang-Hsu Chiang; Guo-Rung You; Hsin-Ying Chen; Ann-Joy Cheng
Journal:  Oncotarget       Date:  2017-01-03

5.  ALCAM+ stromal cells: role in giant cell tumor of bone progression.

Authors:  Zhenhua Zhou; Yan Li; Xudong Wang; Jingjing Hu; Muyu Kuang; Zhiwei Wang; Song Li; Weidong Xu; Jianru Xiao
Journal:  Cell Death Dis       Date:  2018-02-20       Impact factor: 8.469

Review 6.  Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation.

Authors:  Yi-Chen Li; Ann-Joy Cheng; Li-Yu Lee; Yu-Chen Huang; Joseph Tung-Chieh Chang
Journal:  J Cancer       Date:  2019-07-08       Impact factor: 4.207

7.  What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.

Authors:  Komal Qureshi-Baig; Pit Ullmann; Fabien Rodriguez; Sónia Frasquilho; Petr V Nazarov; Serge Haan; Elisabeth Letellier
Journal:  PLoS One       Date:  2016-01-08       Impact factor: 3.240

8.  MiR-520b as a novel molecular target for suppressing stemness phenotype of head-neck cancer by inhibiting CD44.

Authors:  Ya-Ching Lu; Ann-Joy Cheng; Li-Yu Lee; Guo-Rung You; Yan-Liang Li; Hsin-Ying Chen; Joseph T Chang
Journal:  Sci Rep       Date:  2017-05-17       Impact factor: 4.379
  8 in total

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