Literature DB >> 25920015

Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose-volume analysis.

Rosario Mazzola1,2, Francesco Ricchetti1, Sergio Fersino1, Alba Fiorentino1, Niccolò Giaj Levra1, Gioacchino Di Paola3, Ruggero Ruggieri1, Filippo Alongi1.   

Abstract

BACKGROUND: The purpose of this study was to assess predictors of mucositis in oropharyngeal and oral cavity cancer after definitive or adjuvant volumetric modulated arc radiotherapy (VMAT) +/- chemotherapy.
METHODS: Fifty patients were evaluated. Statistical analysis was performed for the following parameters as potential predictors of mucositis ≥ G2: total oral mucosa and oral mucosa minus target high-low radiation dose regions (planning target volumes [PTVs]), mean dose (Dmean ), maximum dose (Dmax ), chemotherapy, weight loss, and dysphagia.
RESULTS: Mucositis ≥ G2 was found to be statistically related to chemotherapy, weight loss, dysphagia ≥ G2, total oral mucosa Dmean ≥50 Gy and Dmax ≥65 Gy, V45 Gy >40%, V50 Gy >30%, and V55 Gy >20% of the oral mucosa minus target PTVs. A ratio between total oral mucosa and oral mucosa minus target PTVs >2.5 is related to G3 mucositis (p = .03).
CONCLUSION: New parameters were found as predictors of moderate-severe mucositis.
© 2015 Wiley Periodicals, Inc. Head Neck 38: E815-E819, 2016. © 2015 Wiley Periodicals, Inc.

Entities:  

Keywords:  head neck cancer; mucositis; organ sparing; volumetric modulated arc radiotherapy (VMAT)

Mesh：

Year:  2015        PMID： 25920015     DOI： 10.1002/hed.24106

Source DB:  PubMed          Journal:  Head Neck        ISSN： 1043-3074            Impact factor:   3.147


  13 in total

1.  Cone-beam computed tomography in lung stereotactic ablative radiation therapy: predictive parameters of early response.

Authors:  Rosario Mazzola; Alba Fiorentino; Francesco Ricchetti; Niccolò Giaj Levra; Sergio Fersino; Gioacchino Di Paola; Antonio Lo Casto; Ruggero Ruggieri; Filippo Alongi
Journal:  Br J Radiol       Date:  2016-06-01       Impact factor: 3.039

2.  18F-Fluorodeoxyglucose-PET/CT in locally advanced head and neck cancer can influence the stage migration and nodal radiation treatment volumes.

Authors:  Rosario Mazzola; Pierpaolo Alongi; Francesco Ricchetti; Alba Fiorentino; Sergio Fersino; Niccolò Giaj-Levra; Matteo Salgarello; Filippo Alongi
Journal:  Radiol Med       Date:  2017-08-28       Impact factor: 3.469

3.  Fentanyl pectin nasal spray for painful mucositis in head and neck cancers during intensity-modulated radiation therapy with or without chemotherapy.

Authors:  R Mazzola; F Ricchetti; A Fiorentino; N Giaj-Levra; S Fersino; U Tebano; S Albanese; S Gori; F Alongi
Journal:  Clin Transl Oncol       Date:  2016-11-16       Impact factor: 3.405

4.  Effectiveness of tapentadol prolonged release for the management of painful mucositis in head and neck cancers during intensity modulated radiation therapy.

Authors:  Mazzola Rosario; Ricchetti Francesco; Fersino Sergio; Giaj Levra Niccolò; Fiorentino Alba; Nicodemo Maurizio; Albanese Sergio; Gori Stefania; Alongi Filippo
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Authors:  R Mazzola; F Ricchetti; A Fiorentino; G Di Paola; S Fersino; N Giaj Levra; R Ruggieri; F Alongi
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6.  Pretreatment predictive factors for feasibility of oral intake in adjuvant concurrent chemoradiotherapy for patients with locally advanced squamous cell carcinoma of the head and neck.

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Authors:  Hui Chang; Kai Chen; Ya-Lan Tao; Fei Han; Wei-Jun Ye; Yuan-Hong Gao
Journal:  Radiat Oncol       Date:  2020-06-05       Impact factor: 3.481

9.  Radiologic criteria of retropharyngeal lymph node metastasis in maxillary sinus cancer.

Authors:  Yasuo Kosugi; Michimasa Suzuki; Mitsuhisa Fujimaki; Shinichi Ohba; Fumihiko Matsumoto; Yoichi Muramoto; Terufumi Kawamoto; Masaki Oshima; Naoto Shikama; Keisuke Sasai
Journal:  Radiat Oncol       Date:  2021-09-26       Impact factor: 3.481

10.  Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities.

Authors:  Qing-Qing Xu; Yan-Zhen Lai; Zi-Lu Huang; Zi-Yi Zeng; Ya-Ni Zhang; Rui-Yao Ou; Wen-Min Wu; Lei Chen; Li-Xia Lu
Journal:  Radiat Oncol       Date:  2021-07-28       Impact factor: 3.481
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