Literature DB >> 2591972

Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.

T C Gilliam1, N B Freimer, C A Kaufmann, P P Powchik, A S Bassett, U Bengtsson, J J Wasmuth.   

Abstract

Two independent lines of evidence support the localization of a schizophrenia susceptibility locus to the proximal long arm of chromosome 5. A partial trisomy of chromosome 5 (5q11.2-q13.3) cosegregates with the disorder in a Canadian family of Chinese descent, and DNA markers from proximal 5q cosegregate with schizophrenia (plus related disorders) in families of British and Icelandic descent. We constructed a human:hamster hybrid cell line (HHW 1064) whose only human complement is a chromosome 5 that is missing the trisomic region associated with schizophrenia. In combination with a "matched" cell hybrid (HHW 105) containing an intact chromosome 5, we physically mapped DNA markers relative to the trisomy. "Schizophrenia-linked" DNA markers p105-153Ra (D5S39) and p105-599Ha (D5S76) map within the trisomy and proximal to the 5q11.2 breakpoint, respectively. The hybrid cell lines HHW 105 and HHW 1064 together provide a means to identify and generate syntenic DNA markers to further investigate the location of a schizophrenia locus.

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Year:  1989        PMID： 2591972      PMCID： PMC3154173          DOI： 10.1016/0888-7543(89)90138-9

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  18 in total

1.  An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.

Authors:  B K Kobilka; T Frielle; S Collins; T Yang-Feng; T S Kobilka; U Francke; R J Lefkowitz; M G Caron
Journal:  Nature       Date:  1987 Sep 3-9       Impact factor: 49.962

2.  An anonymous human single copy genomic clone, D5S6 (M4) on chromosome 5 identifies a three allele RFLP.

Authors:  E Dietzsch; A E Retief; M J Lotze; L Warnich; D L Nicholson; M F Fox; J Fricke; L du Plessis; C J Oosthuizen
Journal:  Nucleic Acids Res       Date:  1986-02-25       Impact factor: 16.971

3.  Glucocorticoid receptor maps to the distal long arm of chromosome 5.

Authors:  L A Giuffra; J L Kennedy; C M Castiglione; R M Evans; J J Wasmuth; K K Kidd
Journal:  Cytogenet Cell Genet       Date:  1988

4.  Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5q.

Authors:  C A Kaufmann; L E DeLisi; T Lehner; T C Gilliam
Journal:  Schizophr Bull       Date:  1989       Impact factor: 9.306

5.  Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

Authors:  R G Korneluk; D J Mahuran; K Neote; M H Klavins; B F O'Dowd; M Tropak; H F Willard; M J Anderson; J A Lowden; R A Gravel
Journal:  J Biol Chem       Date:  1986-06-25       Impact factor: 5.157

6.  The functional human dihydrofolate reductase gene.

Authors:  M J Chen; T Shimada; A D Moulton; A Cline; R K Humphries; J Maizel; A W Nienhuis
Journal:  J Biol Chem       Date:  1984-03-25       Impact factor: 5.157

7.  Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.

Authors:  T C Gilliam; R E Tanzi; J L Haines; T I Bonner; A G Faryniarz; W J Hobbs; M E MacDonald; S V Cheng; S E Folstein; P M Conneally
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

8.  Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.

Authors:  S Dana; J J Wasmuth
Journal:  Mol Cell Biol       Date:  1982-10       Impact factor: 4.272

9.  Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion.

Authors:  L M Kunkel; A P Monaco; W Middlesworth; H D Ochs; S A Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

10.  Primary structure and expression of a functional human glucocorticoid receptor cDNA.

Authors:  S M Hollenberg; C Weinberger; E S Ong; G Cerelli; A Oro; R Lebo; E B Thompson; M G Rosenfeld; R M Evans
Journal:  Nature       Date:  1985-12-19       Impact factor: 49.962
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  17 in total

1.  Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism.

Authors:  L Almasy; B Porjesz; J Blangero; A Goate; H J Edenberg; D B Chorlian; S Kuperman; S J O'Connor; J Rohrbaugh; L O Bauer; T Foroud; J P Rice; T Reich; H Begleiter
Journal:  Am J Hum Genet       Date:  2000-12-01       Impact factor: 11.025

Review 2.  Dopamine receptor genes: new tools for molecular psychiatry.

Authors:  H B Niznik; H H Van Tol
Journal:  J Psychiatry Neurosci       Date:  1992-10       Impact factor: 6.186

3.  Refinement of the spinal muscular atrophy locus by genetic and physical mapping.

Authors:  C H Wang; P W Kleyn; E Vitale; B M Ross; L Lien; J Xu; T A Carter; L M Brzustowicz; S Obici; S Selig
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

Review 4.  Paternal duplication of chromosome 5q11.2-5q14 in a male born with craniostenosis, ear tags, kidney dysplasia and several other anomalies.

Authors:  E J Breslau-Siderius; J T Wijnen; J G Dauwerse; J M de Pater; F A Beemer; P M Khan
Journal:  Hum Genet       Date:  1993-11       Impact factor: 4.132

5.  A sublocus of the multicopy microsatellite marker CMS1 maps proximal to spinal muscular atrophy (SMA) as shown by recombinant analysis.

Authors:  G van der Steege; J M Cobben; J Osinga; H Scheffer; G J van Ommen; C H Buys
Journal:  Hum Genet       Date:  1995-11       Impact factor: 4.132

6.  Use of genetic and physical mapping to locate the spinal muscular atrophy locus between two new highly polymorphic DNA markers.

Authors:  O Clermont; P Burlet; L Burglen; S Lefebvre; F Pascal; J McPherson; J J Wasmuth; D Cohen; D Le Paslier; J Weissenbach
Journal:  Am J Hum Genet       Date:  1994-04       Impact factor: 11.025

7.  A recombination event occurring within two complex 5q13.1 microsatellite repeat polymorphisms suggests a telomeric mapping of spinal muscular atrophy.

Authors:  Z Yaraghi; M D McLean; N Roy; L Surh; J E Ikeda; R G Korneluk; A MacKenzie
Journal:  Hum Genet       Date:  1995-09       Impact factor: 4.132

8.  Cosegregation of schizophrenia with Becker muscular dystrophy: susceptibility locus for schizophrenia at Xp21 or an effect of the dystrophin gene in the brain?

Authors:  M Zatz; H Vallada; M S Melo; M R Passos-Bueno; A H Vieira; M Vainzof; M Gill; V Gentil
Journal:  J Med Genet       Date:  1993-02       Impact factor: 6.318

9.  Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1).

Authors:  F Tissir; B Champagne; K Klinga-Levan; G Levan; J Szpirer; C Szpirer
Journal:  Mamm Genome       Date:  1996-03       Impact factor: 2.957

10.  High-resolution genetic map around the spinal muscular atrophy (SMA) locus on chromosome 5.

Authors:  K E Morrison; R J Daniels; G K Suthers; G A Flynn; M J Francis; V J Buckle; K E Davies
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025
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