Literature DB >> 25918139

First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France.

Rose-Anne Lavergne1, Florent Morio1, Loïc Favennec2, Stéphane Dominique3, Jacques F Meis4, Gilles Gargala2, Paul E Verweij5, Patrice Le Pape6.   

Abstract

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25918139      PMCID： PMC4468656          DOI： 10.1128/AAC.00127-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India.

Authors:  Anuradha Chowdhary; Cheshta Sharma; Shallu Kathuria; Ferry Hagen; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2013-10-01       Impact factor: 5.790

Review 2.  Azole resistance in Aspergillus fumigatus: a growing public health concern.

Authors:  Edith Vermeulen; Katrien Lagrou; Paul E Verweij
Journal:  Curr Opin Infect Dis       Date:  2013-12       Impact factor: 4.915

3.  New case of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in Belgium.

Authors:  Isabel Montesinos; Magali Dodemont; Katrien Lagrou; Frederique Jacobs; Isabelle Etienne; Olivier Denis
Journal:  J Antimicrob Chemother       Date:  2014-08-01       Impact factor: 5.790

4.  Prevalence and molecular characterization of azole resistance in Aspergillus spp. isolates from German cystic fibrosis patients.

Authors:  J Fischer; S van Koningsbruggen-Rietschel; E Rietschel; M J G T Vehreschild; H Wisplinghoff; M Krönke; A Hamprecht
Journal:  J Antimicrob Chemother       Date:  2014-01-31       Impact factor: 5.790

5.  First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.

Authors:  K M T Astvad; R H Jensen; T M Hassan; E G Mathiasen; G M Thomsen; U G Pedersen; M Christensen; O Hilberg; M C Arendrup
Journal:  Antimicrob Agents Chemother       Date:  2014-06-16       Impact factor: 5.191

6.  Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012.

Authors:  E Vermeulen; J Maertens; H Schoemans; K Lagrou
Journal:  Euro Surveill       Date:  2012-11-29

7.  Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania.

Authors:  Anuradha Chowdhary; Cheshta Sharma; Mara van den Boom; Jan Bart Yntema; Ferry Hagen; Paul E Verweij; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2014-07-07       Impact factor: 5.790

8.  Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles.

Authors:  Jan W M van der Linden; Simone M T Camps; Greetje A Kampinga; Jan P A Arends; Yvette J Debets-Ossenkopp; Pieter J A Haas; Bart J A Rijnders; Ed J Kuijper; Frank H van Tiel; János Varga; Anna Karawajczyk; J Zoll; Willem J G Melchers; Paul E Verweij
Journal:  Clin Infect Dis       Date:  2013-05-10       Impact factor: 9.079

9.  High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis.

Authors:  Florent Morio; Guillaume G Aubin; Isabelle Danner-Boucher; Alain Haloun; Emilie Sacchetto; Dea Garcia-Hermoso; Stéphane Bretagne; Michel Miegeville; Patrice Le Pape
Journal:  J Antimicrob Chemother       Date:  2012-05-11       Impact factor: 5.790

Review 10.  Emergence of azole-resistant aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health.

Authors:  Anuradha Chowdhary; Shallu Kathuria; Jianping Xu; Jacques F Meis
Journal:  PLoS Pathog       Date:  2013-10-24       Impact factor: 6.823
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  26 in total

1.  Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China.

Authors:  Yong Chen; Zhongyi Lu; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E Verweij; Liuyu Huang; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

Review 2.  Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.

Authors:  Jacques F Meis; Anuradha Chowdhary; Johanna L Rhodes; Matthew C Fisher; Paul E Verweij
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-05       Impact factor: 6.237

Review 3.  Antifungal Susceptibility Testing: Current Approaches.

Authors:  Elizabeth L Berkow; Shawn R Lockhart; Luis Ostrosky-Zeichner
Journal:  Clin Microbiol Rev       Date:  2020-04-29       Impact factor: 26.132

Review 4.  Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern?

Authors:  A Hamprecht; F Morio; O Bader; P Le Pape; J Steinmann; E Dannaoui
Journal:  Mycopathologia       Date:  2017-06-26       Impact factor: 2.574

5.  Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides.

Authors:  Jianhua Zhang; Joost van den Heuvel; Alfons J M Debets; Paul E Verweij; Willem J G Melchers; Bas J Zwaan; Sijmen E Schoustra
Journal:  Proc Biol Sci       Date:  2017-09-27       Impact factor: 5.349

6.  In Vivo Efficacy of Liposomal Amphotericin B against Wild-Type and Azole-Resistant Aspergillus fumigatus Isolates in Two Different Immunosuppression Models of Invasive Aspergillosis.

Authors:  Seyedmojtaba Seyedmousavi; Johan W Mouton; Willem J G Melchers; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

Review 7.  Triazole Resistance in Aspergillus Species: An Emerging Problem.

Authors:  Rocio Garcia-Rubio; Manuel Cuenca-Estrella; Emilia Mellado
Journal:  Drugs       Date:  2017-04       Impact factor: 9.546

Review 8.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

Review 9.  Emerging Fungal Threats in Cystic Fibrosis.

Authors:  C Schwarz; P Eschenhagen; J P Bouchara
Journal:  Mycopathologia       Date:  2021-07-28       Impact factor: 2.574

10.  Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China.

Authors:  Duantao Cao; Ruilin Wu; Suxia Dong; Feiyan Wang; Chao Ju; Sumei Yu; Shiji Xu; Hua Fang; Yunlong Yu
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191
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