Literature DB >> 23218390

Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012.

E Vermeulen1, J Maertens, H Schoemans, K Lagrou.   

Abstract

A new azole resistance mechanism in Aspergillus fumigatus consisting of a TR46/Y121F/T289A alteration in the cyp51A gene was recently described in the Netherlands. Strains containing these mutations are associated with invasive infection and therapy failure. This communication describes the first case of fatal invasive aspergillosis caused by TR46/Y121F/T289A outside the Netherlands, in the neighboring country of Belgium, suggesting geographical spread. TR46/Y121F/T289A leads to a recognisable phenotypic susceptibility pattern which should trigger cyp51A genotyping to monitor further spread.

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Year:  2012        PMID： 23218390

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


  38 in total

1.  Emergence of TR46/Y121F/T289A in an Aspergillus fumigatus isolate from a Chinese patient.

Authors:  Yong Chen; Huan Wang; Zhongyi Lu; Peng Li; Qing Zhang; Tianye Jia; Jingya Zhao; Shuguang Tian; Xuelin Han; Fangyan Chen; Changjian Zhang; Xiaodong Jia; Liuyu Huang; Fen Qu; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

2.  Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China.

Authors:  Yong Chen; Zhongyi Lu; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E Verweij; Liuyu Huang; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

Review 3.  Emerging threat of triazole-resistant Aspergillus fumigatus.

Authors:  Jeffrey M Rybak; Jarrod R Fortwendel; P David Rogers
Journal:  J Antimicrob Chemother       Date:  2019-04-01       Impact factor: 5.790

4.  Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors.

Authors:  Mark T Roundtree; Praveen R Juvvadi; E Keats Shwab; D Christopher Cole; William J Steinbach
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

5.  The strength of synergistic interaction between posaconazole and caspofungin depends on the underlying azole resistance mechanism of Aspergillus fumigatus.

Authors:  Eleftheria Mavridou; Joseph Meletiadis; Antony Rijs; Johan W Mouton; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2015-01-12       Impact factor: 5.191

Review 6.  Aspergillus fumigatus and aspergillosis: From basics to clinics.

Authors:  A Arastehfar; A Carvalho; J Houbraken; L Lombardi; R Garcia-Rubio; J D Jenks; O Rivero-Menendez; R Aljohani; I D Jacobsen; J Berman; N Osherov; M T Hedayati; M Ilkit; D James-Armstrong; T Gabaldón; J Meletiadis; M Kostrzewa; W Pan; C Lass-Flörl; D S Perlin; M Hoenigl
Journal:  Stud Mycol       Date:  2021-05-10       Impact factor: 16.097

7.  Culture-Based Methods and Molecular Tools for Azole-Resistant Aspergillus fumigatus Detection in a Belgian University Hospital.

Authors:  I Montesinos; M A Argudín; M Hites; F Ahajjam; M Dodémont; C Dagyaran; M Bakkali; I Etienne; F Jacobs; C Knoop; S Patteet; K Lagrou
Journal:  J Clin Microbiol       Date:  2017-05-17       Impact factor: 5.948

8.  First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France.

Authors:  Rose-Anne Lavergne; Florent Morio; Loïc Favennec; Stéphane Dominique; Jacques F Meis; Gilles Gargala; Paul E Verweij; Patrice Le Pape
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

9.  First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.

Authors:  K M T Astvad; R H Jensen; T M Hassan; E G Mathiasen; G M Thomsen; U G Pedersen; M Christensen; O Hilberg; M C Arendrup
Journal:  Antimicrob Agents Chemother       Date:  2014-06-16       Impact factor: 5.191

Review 10.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132
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