Enrico Cecchi1, Fabio Chirillo2, Anna Castiglione3, Pompilio Faggiano4, Moreno Cecconi5, Antonella Moreo6, Alessandro Cialfi7, Mauro Rinaldi8, Stefano Del Ponte9, Angelo Squeri10, Silvia Corcione11, Francesca Canta12, Oscar Gaddi13, Francesco Enia14, Davide Forno1, Piera Costanzo15, Alfredo Zuppiroli16, Giuliana Ronzani17, Flavio Bologna18, Anna Patrignani19, Riccardo Belli1, Giovannino Ciccone3, Francesco Giuseppe De Rosa11. 1. Department of Cardiology, Maria Vittoria Hospital, Torino, Italy. 2. Department of Cardiology, Ca' Foncello Hospital, Treviso, Italy. 3. SSCVD Epidemiologia Clinica e Valutativa, Città della Salute e della Scienza di Torino, Italy. 4. Department of Cardiology, University of Brescia, Brescia, Italy. 5. Dipartimento di Scienze Cardiologiche Mediche e Chirurgiche Azienda Ospedaliera Universitaria, Ospedali Riuniti, Ancona, Italy. 6. Department of Cardiology, Niguarda Ca' Granda Hospital, Milano, Italy. 7. Department of Cardiac Surgery, Sacco Hospital, Milano, Italy. 8. Department of Cardiac Surgery, Molinette Hospital, University of Torino, Torino, Italy. 9. Department of Cardiac Surgery, Mauriziano Hospital, Torino, Italy. 10. Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliera - Universitaria di Parma, Parma, Italy. 11. Department of Medical Sciences, University of Turin; Infectious Diseases at Amedeo di Savoia Hospital, Turin, Italy. 12. Ospedale di Chieri, Italy. 13. Department of Cardiology, Reggio Emilia Hospital, Reggio Emilia, Italy. 14. Department of Cardiology, Cervello Hospital, Palermo, Italy. 15. Department of Cardiology, Giovanni Bosco Hospital, Torino, Italy. 16. Department of Cardiology, Firenze Hospital, Firenze, Italy. 17. Department of Cardiology, Ivrea Hospital, Ivrea, Italy. 18. Department of Cardiology, Rimini Hospital, Rimini, Italy. 19. Department of Cardiology, Senigallia Hospital, Senigallia, Italy.
Abstract
INTRODUCTION: The epidemiology of infective endocarditis (IE) is changing due to a number of factors, including aging and health related comorbidities and medical procedures. The aim of this study is to describe the main clinical, epidemiologic and etiologic changes of IE from a large database in Italy. METHODS: We prospectively collected episodes of IE in 17 Italian centers from July 2007 to December 2010. RESULTS: We enrolled 677 patients with definite IE, of which 24% health-care associated. Patients were male (73%) with a median age of 62 years (IQR: 49-74) and 61% had several comorbidities. One hundred and twenty-eight (19%) patients had prosthetic left side IE, 391 (58%) native left side IE, 94 (14%) device-related IE and 54 (8%) right side IE. A predisposing cardiopathy was present in 50%, while odontoiatric and non odontoiatric procedures were reported in 5% and 21% of patients respectively. Symptoms were usually atypical and precocious. The prevalent etiology was represented by Staphylococcus aureus (27%) followed by coagulase-negative staphylococci (CNS, 21%), Streptococcus viridans (15%) and enterococci (14%). CNS and enterococci were relatively more frequent in patients with intravascular devices and prosthesis and S. viridans in left native valve. Diagnosis was made by transthoracic and transesophageal echocardiography in 62% and 94% of cases, respectively. The in-hospital mortality was 14% and 1-year mortality was 21%. CONCLUSION: The epidemiology is changing in Italy, where IE more often affects older patients with comorbidities and intravascular devices, with an acute onset and including a high frequency of enterococci. There were few preceding odontoiatric procedures.
INTRODUCTION: The epidemiology of infective endocarditis (IE) is changing due to a number of factors, including aging and health related comorbidities and medical procedures. The aim of this study is to describe the main clinical, epidemiologic and etiologic changes of IE from a large database in Italy. METHODS: We prospectively collected episodes of IE in 17 Italian centers from July 2007 to December 2010. RESULTS: We enrolled 677 patients with definite IE, of which 24% health-care associated. Patients were male (73%) with a median age of 62 years (IQR: 49-74) and 61% had several comorbidities. One hundred and twenty-eight (19%) patients had prosthetic left side IE, 391 (58%) native left side IE, 94 (14%) device-related IE and 54 (8%) right side IE. A predisposing cardiopathy was present in 50%, while odontoiatric and non odontoiatric procedures were reported in 5% and 21% of patients respectively. Symptoms were usually atypical and precocious. The prevalent etiology was represented by Staphylococcus aureus (27%) followed by coagulase-negative staphylococci (CNS, 21%), Streptococcus viridans (15%) and enterococci (14%). CNS and enterococci were relatively more frequent in patients with intravascular devices and prosthesis and S. viridans in left native valve. Diagnosis was made by transthoracic and transesophageal echocardiography in 62% and 94% of cases, respectively. The in-hospital mortality was 14% and 1-year mortality was 21%. CONCLUSION: The epidemiology is changing in Italy, where IE more often affects older patients with comorbidities and intravascular devices, with an acute onset and including a high frequency of enterococci. There were few preceding odontoiatric procedures.
Authors: Mohammad Amin Kashef; Jennifer Friderici; Jaime Hernandez-Montfort; Auras R Atreya; Peter Lindenauer; Tara Lagu Journal: J Hosp Med Date: 2017-06 Impact factor: 2.960
Authors: F Gouriet; H Chaudet; P Gautret; L Pellegrin; V P de Santi; H Savini; G Texier; D Raoult; P-E Fournier Journal: New Microbes New Infect Date: 2018-05-30
Authors: Yuka Kiyota; Alessandro Della Corte; Vanessa Montiero Vieira; Karam Habchi; Chuan-Chin Huang; Ester E Della Ratta; Thoralf M Sundt; Prem Shekar; Jochen D Muehlschlegel; Simon C Body Journal: Open Heart Date: 2017-05-16
Authors: Guillermo Cuervo; Alexander Rombauts; Queralt Caballero; Immaculada Grau; Miquel Pujol; Carmen Ardanuy; Dámaris Berbel; Carlota Gudiol; Jose Carlos Sánchez-Salado; Alejandro Ruiz-Majoral; Fabrizio Sbraga; Laura Gracia-Sánchez; Carmen Peña; Jordi Carratalà Journal: Open Forum Infect Dis Date: 2018-07-27 Impact factor: 3.835