OBJECTIVE: To investigate the relationship between IL-6 -174G/C promoter polymorphism and preeclampsia. METHODS: A total of 140 preeclamptic women and 135 women with normal pregnancy were considered for the present study. A standard amplification refractory mutation system PCR was carried out for genotyping of IL-6 G-174C promoter polymorphism. Genotypic distribution was compared with values predicted by Hardy-Weinberg equilibrium using χ (2) test. Odds ratios and their respective 95 % confidence intervals were used to measure the strength of association. RESULTS: The frequencies observed, CC, GC and GG, were 53.5, 26.6 and 20 % in patients and 26.6, 23.7 and 49.6 % in the controls. There is a significant difference in the distribution of genotypes and alleles of IL-6 G-174 C between the two groups. CONCLUSION: The present study suggests that the IL-6 -174 promoter polymorphism is a major genetic regulator in the etiology of early-onset preeclampsia.
OBJECTIVE: To investigate the relationship between IL-6-174G/C promoter polymorphism and preeclampsia. METHODS: A total of 140 preeclamptic women and 135 women with normal pregnancy were considered for the present study. A standard amplification refractory mutation system PCR was carried out for genotyping of IL-6G-174C promoter polymorphism. Genotypic distribution was compared with values predicted by Hardy-Weinberg equilibrium using χ (2) test. Odds ratios and their respective 95 % confidence intervals were used to measure the strength of association. RESULTS: The frequencies observed, CC, GC and GG, were 53.5, 26.6 and 20 % in patients and 26.6, 23.7 and 49.6 % in the controls. There is a significant difference in the distribution of genotypes and alleles of IL-6G-174 C between the two groups. CONCLUSION: The present study suggests that the IL-6 -174 promoter polymorphism is a major genetic regulator in the etiology of early-onset preeclampsia.
Authors: J Ellis; U B Wennerholm; A Bengtsson; H Lilja; A Pettersson; B Sultan; M Wennergren; H Hagberg Journal: Acta Obstet Gynecol Scand Date: 2001-07 Impact factor: 3.636
Authors: Ali S Khashan; Marie Evans; Marius Kublickas; Fergus P McCarthy; Louise C Kenny; Peter Stenvinkel; Tony Fitzgerald; Karolina Kublickiene Journal: PLoS Med Date: 2019-07-30 Impact factor: 11.069
Authors: José Pacheco-Romero; Oscar Acosta; Doris Huerta; Santiago Cabrera; Marlene Vargas; Pedro Mascaro; Moisés Huamán; José Sandoval; Rudy López; Julio Mateus; Enrique Gil; Enrique Guevara; Nitza Butrica; Diana Catari; David Bellido; Gina Custodio; Andrea Naranjo Journal: Colomb Med (Cali) Date: 2021-02-26