Literature DB >> 25916575

Fluoride in drinking water and diet: the causative factor of chronic kidney diseases in the North Central Province of Sri Lanka.

Ranjith W Dharmaratne1.   

Abstract

A significant number of people in the North Central Province of Sri Lanka suffer from chronic kidney diseases (CKD), and the author revisits existing literature related to CKD to find its causative factor. There is a direct connection between high fluoride levels in drinking water and kidney disease, and there are unhealthy levels of fluoride in the groundwater in Sri Lanka's CKD-affected areas. Based on the following observations, the author believes with confidence that excess fluoride in drinking water and in the locally grown food in the affected areas are the culprits of CKD in Sri Lanka. Fluoride excretion rate is considerably lower in children than adults, leading to renal damage of children living in areas with high fluoride. Adults who had renal damage due to fluoride in childhood are vulnerable to CKD with continued consumption of water from the same source. Patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. High content of fluoride in groundwater paves the way to excess fluoride in local food crops, consequently adding more fluoride to the systems of the consumers. People who work outdoors for prolonged periods consume excess water and tea, and are subjected to additional doses of fluoride in their system. In the mid-1980s, the increase in water table levels of the affected areas due to new irrigation projects paved the way to adding more fluorides to their system through drinking water and locally grown foods.

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Year:  2015        PMID: 25916575      PMCID: PMC4491063          DOI: 10.1007/s12199-015-0464-4

Source DB:  PubMed          Journal:  Environ Health Prev Med        ISSN: 1342-078X            Impact factor:   3.674


  18 in total

1.  [The dose-effect relationship of water fluoride levels and renal damage in children].

Authors:  Jun-Ling Liu; Tao Xia; Yao-Yong Yu; Xian-Zhong Sun; Qilong Zhu; Weihong He; Ming Zhang; Aiguo Wang
Journal:  Wei Sheng Yan Jiu       Date:  2005-05

2.  Global Voices of Science. Of stones and health: medical geology in Sri Lanka.

Authors:  Chandrasekara Dissanayake
Journal:  Science       Date:  2005-08-05       Impact factor: 47.728

3.  Fluoridation of drinking water and chronic kidney disease: absence of evidence is not evidence of absence.

Authors:  Helmut Schiffl
Journal:  Nephrol Dial Transplant       Date:  2007-10-03       Impact factor: 5.992

4.  Effects of fluoridation of community water supplies for people with chronic kidney disease.

Authors:  Marie Ludlow; Grant Luxton; Timothy Mathew
Journal:  Nephrol Dial Transplant       Date:  2007-07-27       Impact factor: 5.992

5.  Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children.

Authors:  Xianzhi Xiong; Junling Liu; Weihong He; Tao Xia; Ping He; Xuemin Chen; Kedi Yang; Aiguo Wang
Journal:  Environ Res       Date:  2006-07-10       Impact factor: 6.498

6.  Chronic kidney disease of unknown aetiology and ground-water ionicity: study based on Sri Lanka.

Authors:  M W C Dharma-Wardana; Sarath L Amarasiri; Nande Dharmawardene; C R Panabokke
Journal:  Environ Geochem Health       Date:  2014-08-14       Impact factor: 4.609

7.  Chronic renal failure among farm families in cascade irrigation systems in Sri Lanka associated with elevated dietary cadmium levels in rice and freshwater fish (Tilapia).

Authors:  J M R S Bandara; D M A N Senevirathna; D M R S B Dasanayake; V Herath; J M R P Bandara; T Abeysekara; K H Rajapaksha
Journal:  Environ Geochem Health       Date:  2008-01-17       Impact factor: 4.609

Review 8.  Cadmium, diabetes and chronic kidney disease.

Authors:  Joshua R Edwards; Walter C Prozialeck
Journal:  Toxicol Appl Pharmacol       Date:  2009-03-24       Impact factor: 4.219

9.  World salinization with emphasis on Australia.

Authors:  Pichu Rengasamy
Journal:  J Exp Bot       Date:  2006-03-01       Impact factor: 6.992

10.  Fluoride-induced chronic renal failure.

Authors:  O Lantz; M H Jouvin; M C De Vernejoul; P Druet
Journal:  Am J Kidney Dis       Date:  1987-08       Impact factor: 8.860

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  11 in total

1.  Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India.

Authors:  Arjun L Khandare; Shankar Rao Gourineni; Vakdevi Validandi
Journal:  Environ Monit Assess       Date:  2017-10-23       Impact factor: 2.513

2.  Diagnosis of Fluorosis by Analysis of Fluoride Content in Body Fluids Using Ion Selective Electrode Method.

Authors:  N K Mondal
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  Improved nanocomposite of montmorillonite and hydroxyapatite for defluoridation of water.

Authors:  M Shanika Fernando; A K D V K Wimalasiri; S P Ratnayake; J M A R B Jayasinghe; Gareth R William; D P Dissanayake; K M Nalin de Silva; Rohini M de Silva
Journal:  RSC Adv       Date:  2019-11-01       Impact factor: 4.036

Review 4.  Endemic Nephropathy Around the World.

Authors:  Fiona J Gifford; Robert M Gifford; Michael Eddleston; Neeraj Dhaun
Journal:  Kidney Int Rep       Date:  2017-03

5.  Assessment of Groundwater Quality in CKDu Affected Areas of Sri Lanka: Implications for Drinking Water Treatment.

Authors:  Titus Cooray; Yuansong Wei; Hui Zhong; Libing Zheng; Sujithra K Weragoda; And Rohan Weerasooriya
Journal:  Int J Environ Res Public Health       Date:  2019-05-14       Impact factor: 3.390

6.  Prevalence and risk factors for impaired kidney function in the district of Anuradhapura, Sri Lanka: a cross-sectional population-representative survey in those at risk of chronic kidney disease of unknown aetiology.

Authors:  Thilanga Ruwanpathirana; Sameera Senanayake; Nalika Gunawardana; Asoka Munasinghe; Samitha Ginige; Deepa Gamage; Jagath Amarasekara; Buddi Lokuketagoda; Pubudu Chulasiri; Sarath Amunugama; Paba Palihawadana; Ben Caplin; Neil Pearce
Journal:  BMC Public Health       Date:  2019-06-14       Impact factor: 3.295

7.  Recent Biomarkers for Monitoring the Systemic Fluoride Levels in Exposed Populations: A Systematic Review.

Authors:  Jesús Lavalle-Carrasco; Nelly Molina-Frechero; Martina Nevárez-Rascón; Leonor Sánchez-Pérez; Aida Hamdan-Partida; Rogelio González-González; Diana Cassi; Mario Alberto Isiordia-Espinoza; Ronell Bologna-Molina
Journal:  Int J Environ Res Public Health       Date:  2021-01-04       Impact factor: 3.390

8.  Evaluation of Performance of Existing RO Drinking Water Stations in the North Central Province, Sri Lanka.

Authors:  Suresh Indika; Yuansong Wei; Dazhou Hu; Jegetheeswaran Ketharani; Tharindu Ritigala; Titus Cooray; M A C K Hansima; Madhubashini Makehelwala; K B S N Jinadasa; Sujithra K Weragoda; Rohan Weerasooriya
Journal:  Membranes (Basel)       Date:  2021-05-24

9.  iTRAQ-Based Proteomics Analysis of Serum Proteins in Wistar Rats Treated with Sodium Fluoride: Insight into the Potential Mechanism and Candidate Biomarkers of Fluorosis.

Authors:  Yan Wei; Beibei Zeng; Hua Zhang; Cheng Chen; Yanli Wu; Nanlan Wang; Yanqiu Wu; Liming Shen
Journal:  Int J Mol Sci       Date:  2016-09-28       Impact factor: 5.923

10.  Experimental rat model for acute tubular injury induced by high water hardness and high water fluoride: efficacy of primary preventive intervention by distilled water administration.

Authors:  Thanusha Perera; Shirani Ranasinghe; Neil Alles; Roshitha Waduge
Journal:  BMC Nephrol       Date:  2020-03-24       Impact factor: 2.388

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