Literature DB >> 25914807

Acid-responsive nanospheres from an asparagine-derived amphiphile.

Adelphe M Mfuh1, Mathew P D Mahindaratne2, Audrey E Yñigez-Gutierrez1, Juan R Ramos Dominguez1, Jefferson T Bedell1, Carlos D Garcia1, George R Negrete1.   

Abstract

We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

Entities:  

Year:  2015        PMID： 25914807      PMCID： PMC4407701          DOI： 10.1039/C4RA11884G

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  33 in total

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