OBJECTIVES: To evaluate the accuracy and change over time of contrast-enhanced ultrasound (US) imaging for assessing residual blood flow after transarterial chemoembolization of hepatocellular carcinoma with drug-eluting beads at 2 different follow-up intervals. METHODS: Data from 16 tumors treated by transarterial chemoembolization with drug-eluting beads were successfully obtained. As part of the study, patients provided consent to undergo contrast-enhanced US examinations the morning before embolization, 1 to 2 weeks after embolization, and the morning before follow-up contrast-enhanced magnetic resonance imaging (MRI) or computed tomography (CT) (1 month after embolization). Blinded review of contrast-enhanced US and MRI/CT studies were performed by 2 radiologists who evaluated residual flow as no change, partial change, or no residual flow. Inter- and intra-reader variability rates were calculated before discordant individual reads were settled by consensus. RESULTS: The only adverse event reported during the contrast-enhanced US examinations was a single episode of transient back pain. Contrast-enhanced US at 1 to 2 weeks after embolization (n = 14) resulted in 100% sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Contrast-enhanced US 1 month after embolization (n = 15) resulted in 75% sensitivity, 100% specificity, 100% positive predictive value, 92% negative predictive value, and 93% accuracy. Inter-reader agreement was 86% for contrast-enhanced US at 1 to 2 weeks, 93% for contrast-enhanced US at 1 month, and 100% for contrast-enhanced MRI/CT at 1 month, whereas intra-reader agreement was 71% for contrast-enhanced US at 1 to 2 weeks, 87% for contrast-enhanced US at 1 month, and 91% for MRI/CT. CONCLUSIONS: Contrast-enhanced US imaging at 1 to 2 weeks after the procedure may be a viable alternative to MRI/CT for evaluating residual blood flow after transarterial chemoembolization with drug-eluting beads, albeit with a higher degree of reader variability.
OBJECTIVES: To evaluate the accuracy and change over time of contrast-enhanced ultrasound (US) imaging for assessing residual blood flow after transarterial chemoembolization of hepatocellular carcinoma with drug-eluting beads at 2 different follow-up intervals. METHODS: Data from 16 tumors treated by transarterial chemoembolization with drug-eluting beads were successfully obtained. As part of the study, patients provided consent to undergo contrast-enhanced US examinations the morning before embolization, 1 to 2 weeks after embolization, and the morning before follow-up contrast-enhanced magnetic resonance imaging (MRI) or computed tomography (CT) (1 month after embolization). Blinded review of contrast-enhanced US and MRI/CT studies were performed by 2 radiologists who evaluated residual flow as no change, partial change, or no residual flow. Inter- and intra-reader variability rates were calculated before discordant individual reads were settled by consensus. RESULTS: The only adverse event reported during the contrast-enhanced US examinations was a single episode of transient back pain. Contrast-enhanced US at 1 to 2 weeks after embolization (n = 14) resulted in 100% sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Contrast-enhanced US 1 month after embolization (n = 15) resulted in 75% sensitivity, 100% specificity, 100% positive predictive value, 92% negative predictive value, and 93% accuracy. Inter-reader agreement was 86% for contrast-enhanced US at 1 to 2 weeks, 93% for contrast-enhanced US at 1 month, and 100% for contrast-enhanced MRI/CT at 1 month, whereas intra-reader agreement was 71% for contrast-enhanced US at 1 to 2 weeks, 87% for contrast-enhanced US at 1 month, and 91% for MRI/CT. CONCLUSIONS: Contrast-enhanced US imaging at 1 to 2 weeks after the procedure may be a viable alternative to MRI/CT for evaluating residual blood flow after transarterial chemoembolization with drug-eluting beads, albeit with a higher degree of reader variability.
Authors: Kibo Nam; Maria Stanczak; Andrej Lyshchik; Priscilla Machado; Yuko Kono; Flemming Forsberg; Colette M Shaw; John R Eisenbrey Journal: Biomed Phys Eng Express Date: 2018-04-18
Authors: Michael R Kramer; Nishi Bhagat; Susan J Back; Laura Poznick; Flemming Forsberg; Kassa Darge; John R Eisenbrey Journal: Pediatr Radiol Date: 2017-09-11
Authors: John R Eisenbrey; Flemming Forsberg; Corinne E Wessner; Lauren J Delaney; Kristen Bradigan; Sriharsha Gummadi; Mohamed Tantawi; Andrej Lyshchik; Patrick O'Kane; Ji-Bin Liu; Charles Intenzo; Jesse Civan; Warren Maley; Scott W Keith; Kevin Anton; Allison Tan; Amanda Smolock; Susan Shamimi-Noori; Colette M Shaw Journal: Radiology Date: 2020-12-15 Impact factor: 11.105
Authors: Lauren J Delaney; Mohamed Tantawi; Corinne E Wessner; Priscilla Machado; Flemming Forsberg; Andrej Lyshchik; Patrick O'Kane; Ji-Bin Liu; Jesse Civan; Allison Tan; Kevin Anton; Colette M Shaw; John R Eisenbrey Journal: Ultrasound Med Biol Date: 2021-06-13 Impact factor: 3.694
Authors: Corinne E Wessner; Colette M Shaw; Maria Stanczak; Flemming Forsberg; Andrej Lyshchik; Allison Tan; John R Eisenbrey Journal: Ultrasound Q Date: 2020-09 Impact factor: 1.462