Mehmet Agirbasli1, Azra Tanrikulu2, Busra Acar Sevim3, Munir Azizy3, Nural Bekiroglu4. 1. Department of Cardiology, Marmara University School of Medicine, Istanbul, Turkey. Electronic address: magirbasli@gmail.com. 2. Department of Cardiology, Maltepe State Hospital, Istanbul, Turkey. 3. Marmara University School of Medicine, Istanbul, Turkey. 4. Department of Biostatistics, Marmara University School of Medicine, Istanbul, Turkey.
Abstract
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is a biomarker of continued long-term systemic inflammation and cardiovascular (CV) risk. OBJECTIVE: To analyze the association of hs-CRP levels with CV risk factors in healthy school children. METHODS: The study sample was derived from a survey on the prevalence of CV risk factors (dyslipidemia, obesity, high blood pressure, and insulin resistance in school children. Along with anthropometry, hs-CRP levels, lipids, glucose levels, and insulin levels were measured. RESULTS: Ninety-one male (12.5 ± 3.4 years) and 77 female students (12.7 ± 3.4; P = .624) were included. Median (interquartile range) hs-CRP levels were similar among boys and girls (0.4 [1.2] vs 0.5 [0.7]; P = .928). Risk factors such as obesity (16%), high triglycerides (20%), low high-density lipoprotein cholesterol (HDL-C, 16%), and elevated blood pressure (25%) were commonly observed in study participants. Gender-stratified analysis displayed that insulin resistance (18 [19.8%] vs 3 [3.9%]; P = .002) and high triglycerides (26 [28.6%] vs 8 [10.4%]; P = .003) were more commonly observed among boys compared with girls. hs-CRP levels correlated positively with cardiometabolic risk factors such as waist circumference (boys) and total cholesterol (TC)-to-HDL-C ratio. Linear regression analysis displayed that among the covariates of age, body mass index, and glucose, TC-to-HDL-C ratio was the most significant determinant of hs-CRP levels (P = .004). CONCLUSION: Cardiometabolic risk factors such as TC-to-HDL-C ratio correlate with hs-CRP levels in children and adolescents. Long-term prospective studies are needed to confirm the association between hs-CRP and cardiometabolic risk in children.
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is a biomarker of continued long-term systemic inflammation and cardiovascular (CV) risk. OBJECTIVE: To analyze the association of hs-CRP levels with CV risk factors in healthy school children. METHODS: The study sample was derived from a survey on the prevalence of CV risk factors (dyslipidemia, obesity, high blood pressure, and insulin resistance in school children. Along with anthropometry, hs-CRP levels, lipids, glucose levels, and insulin levels were measured. RESULTS: Ninety-one male (12.5 ± 3.4 years) and 77 female students (12.7 ± 3.4; P = .624) were included. Median (interquartile range) hs-CRP levels were similar among boys and girls (0.4 [1.2] vs 0.5 [0.7]; P = .928). Risk factors such as obesity (16%), high triglycerides (20%), low high-density lipoprotein cholesterol (HDL-C, 16%), and elevated blood pressure (25%) were commonly observed in study participants. Gender-stratified analysis displayed that insulin resistance (18 [19.8%] vs 3 [3.9%]; P = .002) and high triglycerides (26 [28.6%] vs 8 [10.4%]; P = .003) were more commonly observed among boys compared with girls. hs-CRP levels correlated positively with cardiometabolic risk factors such as waist circumference (boys) and total cholesterol (TC)-to-HDL-C ratio. Linear regression analysis displayed that among the covariates of age, body mass index, and glucose, TC-to-HDL-C ratio was the most significant determinant of hs-CRP levels (P = .004). CONCLUSION: Cardiometabolic risk factors such as TC-to-HDL-C ratio correlate with hs-CRP levels in children and adolescents. Long-term prospective studies are needed to confirm the association between hs-CRP and cardiometabolic risk in children.
Authors: Christopher Beal; Ashraf Gorgey; Pamela Moore; Nathan Wong; Robert A Adler; David Gater Journal: J Spinal Cord Med Date: 2017-08-16 Impact factor: 1.985
Authors: Ernst Mayerhofer; Franz Ratzinger; Nina Elvira Kienreich; Annika Stiel; Nadine Witzeneder; Eva Schrefl; Georg Greiner; Christoph Wegscheider; Irene Graf; Klaus Schmetterer; Rodrig Marculescu; Thomas Szekeres; Thomas Perkmann; Martina Fondi; Oswald Wagner; Harald Esterbauer; Matthias Mayerhofer; Stefana Holocher-Ertl; Claudia Wojnarowski; Gregor Hoermann Journal: Front Pediatr Date: 2020-02-21 Impact factor: 3.418