Naghmeh Mokhber1, Amir Azarpazhooh2,3,4, Elias Orouji5, Bita Khorram5, Morteza Modares Gharavi1, Sorayya Kakhi5, Hoda Khallaghi5, Mahmoud Reza Azarpazhooh5. 1. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Department of Biological and Diagnostic Sciences, Faculty of Dentistry, University of Toronto, Toronto, Canada. 3. Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Canada. 4. Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Toronto, Canada. 5. Department of Neurology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
AIMS: The aim of this study was to evaluate the effect of various disease-modifying therapies (DMT) on quality of life in multiple sclerosis (MS). METHODS: This was a three-arm parallel study with balanced randomization in which 90 newly diagnosed, definite MS subjects referred to Ghaem Medical Center, Mashhad, Iran were enrolled between 2006 and 2009. Patients were randomly allocated into three DMT groups: Avonex, Rebif and Betaferon. Health-related quality of life was assessed in MS patients at baseline and 12 months after treatment with DMT using the MS Quality of Life-54 questionnaire. RESULTS:Both mental and physical health scores improved within all three treatment groups after 12 months of treatment; however, this increase was only significant in the mental health composite in the Betaferon group (P = 0.024). Betaferon had the highest mental health score change (14.04) while this change was 7.26 for Avonex (P = 0.031) and 5.08 for Rebif (P = 0.017). A physical health composite score comparison among the three treatment groups revealed no significant results. CONCLUSIONS: With a positive impact of DMT on mental and physical dimensions of QOL in MS patients, initiation of treatment soon after diagnosis is recommended. In MS patients with more mental issues and fewer physical disabilities, Betaferon might be considered as a better choice of treatment.
RCT Entities:
AIMS: The aim of this study was to evaluate the effect of various disease-modifying therapies (DMT) on quality of life in multiple sclerosis (MS). METHODS: This was a three-arm parallel study with balanced randomization in which 90 newly diagnosed, definite MS subjects referred to Ghaem Medical Center, Mashhad, Iran were enrolled between 2006 and 2009. Patients were randomly allocated into three DMT groups: Avonex, Rebif and Betaferon. Health-related quality of life was assessed in MS patients at baseline and 12 months after treatment with DMT using the MS Quality of Life-54 questionnaire. RESULTS: Both mental and physical health scores improved within all three treatment groups after 12 months of treatment; however, this increase was only significant in the mental health composite in the Betaferon group (P = 0.024). Betaferon had the highest mental health score change (14.04) while this change was 7.26 for Avonex (P = 0.031) and 5.08 for Rebif (P = 0.017). A physical health composite score comparison among the three treatment groups revealed no significant results. CONCLUSIONS: With a positive impact of DMT on mental and physical dimensions of QOL in MS patients, initiation of treatment soon after diagnosis is recommended. In MS patients with more mental issues and fewer physical disabilities, Betaferon might be considered as a better choice of treatment.
Authors: A Ghezzi; A Bianchi; D Baroncini; A Bertolotto; S Malucchi; V Bresciamorra; R Lanzillo; N Milani; V Martinelli; F Patti; C Chisari; M Rottoli; M Simone; D Paolicelli; A Visconti Journal: Neurol Sci Date: 2017-08-22 Impact factor: 3.307
Authors: Matthew J Buettner; Sagar R Shah; Christopher T Saeui; Ryan Ariss; Kevin J Yarema Journal: Front Immunol Date: 2018-11-02 Impact factor: 7.561