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Literature DB >> 25906992

V-cGAPs: attenuators of 3'3'-cGAMP signaling.

Abstract

Cyclic GMP-AMPs (cGAMPs) are new members of the cyclic dinucleotide family of second messenger signaling molecules identified in both bacteria and mammalian cells. A recent study by Gao et al. published in Cell Research has identified and characterized three 3'3'-cGAMP-specific phosphodiesterases (termed as V-cGAP1/2/3) in V. cholerae, thereby providing mechanistic insights into the function of these enzymes that degrade cGAMPs.

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Year: 2015 PMID： 25906992 PMCID： PMC4423086 DOI： 10.1038/cr.2015.48

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

12 in total

1. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.

Authors: Bryan W Davies; Ryan W Bogard; Travis S Young; John J Mekalanos
Journal: Cell Date: 2012-04-13 Impact factor: 41.582

2. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.

Authors: Joshua J Woodward; Anthony T Iavarone; Daniel A Portnoy
Journal: Science Date: 2010-05-27 Impact factor: 47.728

3. An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.

Authors: TuAnh Ngoc Huynh; Shukun Luo; Daniel Pensinger; John-Demian Sauer; Liang Tong; Joshua J Woodward
Journal: Proc Natl Acad Sci U S A Date: 2015-01-12 Impact factor: 11.205

Review 4. Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.

Authors: Ute Römling; Michael Y Galperin; Mark Gomelsky
Journal: Microbiol Mol Biol Rev Date: 2013-03 Impact factor: 11.056

5. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Authors: Pu Gao; Manuel Ascano; Thomas Zillinger; Weiyi Wang; Peihong Dai; Artem A Serganov; Barbara L Gaffney; Stewart Shuman; Roger A Jones; Liang Deng; Gunther Hartmann; Winfried Barchet; Thomas Tuschl; Dinshaw J Patel
Journal: Cell Date: 2013-08-01 Impact factor: 41.582

V-cGAPs: attenuators of 3'3'-cGAMP signaling.

1. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.

2. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.

3. An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.

Review 4. Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.

5. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

6. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

7. STING is a direct innate immune sensor of cyclic di-GMP.

8. Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP.

9. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

Review 10. Cyclic di-AMP: another second messenger enters the fray.

Review 1. Regulating STING in health and disease.