Diane Hu1, Nathan M Young1, Qiuping Xu2, Heather Jamniczky3, Rebecca M Green3, Washington Mio2, Ralph S Marcucio1, Benedikt Hallgrimsson3. 1. Department of Orthopaedic Surgery, San Francisco General Hospital, Orthopaedic Trauma Institute, The University of California at San Francisco, School of Medicine, San Francisco, California. 2. Department of Mathematics, Florida State University, Tallahassee, Florida. 3. Department of Cell Biology and Anatomy, Alberta Children's Research Institute for Child and Maternal Health and the McCaig Bone and Joint Institute, University of Calgary, Calgary, Canada.
Abstract
BACKGROUND: How developmental mechanisms generate the phenotypic variation that is the raw material for evolution is largely unknown. Here, we explore whether variation in a conserved signaling axis between the brain and face contributes to differences in morphogenesis of the avian upper jaw. In amniotes, including both mice and avians, signals from the brain establish a signaling center in the ectoderm (the Frontonasal ectodermal zone or "FEZ") that directs outgrowth of the facial primordia. RESULTS: Here we show that the spatial organization of this signaling center differs among avians, and these correspond to Sonic hedgehog (Shh) expression in the basal forebrain and embryonic facial shape. In ducks this basal forebrain domain is present almost the entire width, while in chickens it is restricted to the midline. When the duck forebrain is unilaterally transplanted into stage matched chicken embryos the face on the treated side resembles that of the donor. CONCLUSIONS: Combined with previous findings, these results demonstrate that variation in a highly conserved developmental pathway has the potential to contribute to evolutionary differences in avian upper jaw morphology. Developmental Dynamics 244:1133-1143, 2015.
BACKGROUND: How developmental mechanisms generate the phenotypic variation that is the raw material for evolution is largely unknown. Here, we explore whether variation in a conserved signaling axis between the brain and face contributes to differences in morphogenesis of the avian upper jaw. In amniotes, including both mice and avians, signals from the brain establish a signaling center in the ectoderm (the Frontonasal ectodermal zone or "FEZ") that directs outgrowth of the facial primordia. RESULTS: Here we show that the spatial organization of this signaling center differs among avians, and these correspond to Sonic hedgehog (Shh) expression in the basal forebrain and embryonic facial shape. In ducks this basal forebrain domain is present almost the entire width, while in chickens it is restricted to the midline. When the duck forebrain is unilaterally transplanted into stage matched chicken embryos the face on the treated side resembles that of the donor. CONCLUSIONS: Combined with previous findings, these results demonstrate that variation in a highly conserved developmental pathway has the potential to contribute to evolutionary differences in avian upper jaw morphology. Developmental Dynamics 244:1133-1143, 2015.
Authors: Galen W Heyne; Cal G Melberg; Padydeh Doroodchi; Kia F Parins; Henry W Kietzman; Joshua L Everson; Lydia J Ansen-Wilson; Robert J Lipinski Journal: PLoS One Date: 2015-03-20 Impact factor: 3.240
Authors: Benedikt Hallgrimsson; Rebecca M Green; David C Katz; Jennifer L Fish; Francois P Bernier; Charles C Roseman; Nathan M Young; James M Cheverud; Ralph S Marcucio Journal: Semin Cell Dev Biol Date: 2018-05-24 Impact factor: 7.727
Authors: Marketa Kaucka; Tomas Zikmund; Marketa Tesarova; Daniel Gyllborg; Andreas Hellander; Josef Jaros; Jozef Kaiser; Julian Petersen; Bara Szarowska; Phillip T Newton; Vyacheslav Dyachuk; Lei Li; Hong Qian; Anne-Sofie Johansson; Yuji Mishina; Joshua D Currie; Elly M Tanaka; Alek Erickson; Andrew Dudley; Hjalmar Brismar; Paul Southam; Enrico Coen; Min Chen; Lee S Weinstein; Ales Hampl; Ernest Arenas; Andrei S Chagin; Kaj Fried; Igor Adameyko Journal: Elife Date: 2017-04-17 Impact factor: 8.140
Authors: Benedikt Hallgrimsson; Christopher J Percival; Rebecca Green; Nathan M Young; Washington Mio; Ralph Marcucio Journal: Curr Top Dev Biol Date: 2015-10-27 Impact factor: 4.897