X-P Liao1, H-W Zhu2, F Zeng3, Z-H Tang4. 1. Department of Internal Medicine, Shanghai Anting Hospital, Jiading, Shanghai, China. xpliao135@163.com. 2. Department of Internal Medicine, Shanghai Anting Hospital, Jiading, Shanghai, China. xavierzhong@yeah.net. 3. Department of Endocrinology and Metabolism, Shanghai Tongji Hospital, Tongji University School of Medicine, Room 517, Building 2nd, 389 Xincun Road, Shanghai, 200063, China. zengfangfang1985@163.com. 4. Department of Endocrinology and Metabolism, Shanghai Tongji Hospital, Tongji University School of Medicine, Room 517, Building 2nd, 389 Xincun Road, Shanghai, 200063, China. albert.tang@163.com.
Abstract
BACKGROUND: The purpose of this study was to evaluate associations among hypertension (HTN) and uric acid (UA) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which synergistic effects of HTN and UA affect the outcome in a Chinese population. METHOD: We conducted a large-scale, population-based study to analyze the association and interaction of the two factors for CAN in a sample of 2092 Chinese people. Univariate and multiple linear regression (MLR) analysis were employed to detect these relationships. Interaction on an additive scale can be calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S). RESULT: After adjusting for confounding factors, MLR showed that HTN was independently associated with CAN (P < 0.001). A significant interaction effect of UA and HTN on CAN was detected (P = 0.035; RETI = 1.483, 95 % CI 0.415-2.551; AP = 0.360, 95 % CI -0.043 to 0.76 and S = 1.908, 95 % CI 0.152-3.66). CONCLUSION: Our findings suggest that HTN is independently and significantly associated with CAN and offer evidence to support the hypothesis that HTN and UA have interaction effects to influence the progression of CAN.
BACKGROUND: The purpose of this study was to evaluate associations among hypertension (HTN) and uric acid (UA) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which synergistic effects of HTN and UA affect the outcome in a Chinese population. METHOD: We conducted a large-scale, population-based study to analyze the association and interaction of the two factors for CAN in a sample of 2092 Chinese people. Univariate and multiple linear regression (MLR) analysis were employed to detect these relationships. Interaction on an additive scale can be calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S). RESULT: After adjusting for confounding factors, MLR showed that HTN was independently associated with CAN (P < 0.001). A significant interaction effect of UA and HTN on CAN was detected (P = 0.035; RETI = 1.483, 95 % CI 0.415-2.551; AP = 0.360, 95 % CI -0.043 to 0.76 and S = 1.908, 95 % CI 0.152-3.66). CONCLUSION: Our findings suggest that HTN is independently and significantly associated with CAN and offer evidence to support the hypothesis that HTN and UA have interaction effects to influence the progression of CAN.
Authors: R W Bian; Q L Lou; L B Gu; A P Kong; W Y So; G T Ko; X J Ouyang; Y Z Mo; R C Ma; J C Chan; C C Chow Journal: Acta Gastroenterol Belg Date: 2011-03 Impact factor: 1.316
Authors: Patricia M Kearney; Megan Whelton; Kristi Reynolds; Paul Muntner; Paul K Whelton; Jiang He Journal: Lancet Date: 2005 Jan 15-21 Impact factor: 79.321
Authors: S Baldasseroni; R Urso; A P Maggioni; F Orso; G Fabbri; N Marchionni; L Tavazzi Journal: Nutr Metab Cardiovasc Dis Date: 2010-12-30 Impact factor: 4.222
Authors: N Papanas; N Katsiki; K Papatheodorou; M Demetriou; D Papazoglou; T Gioka; E Maltezos Journal: Angiology Date: 2011-02-08 Impact factor: 3.619
Authors: Abd A Tahrani; Kiran Dubb; Neil T Raymond; Safia Begum; Quratul A Altaf; Hamed Sadiqi; Milan K Piya; Martin J Stevens Journal: Diabetologia Date: 2014-03-13 Impact factor: 10.122
Authors: Syed Rizwan A Bokhari; Faisal Inayat; Ali Jawa; Hafeez Ul Hasan Virk; Muhammad Awais; Nadeem Hussain; Ghias Ul Hassan; Hafiz Ijaz Ahmad; Hammad S Chaudhry; Abdullah Adil; Ali Haider; Vincent M Figueredo; Janani Rangaswami; Muhammad Zaman Khan Assir Journal: Cureus Date: 2018-08-31