J Guber1, M U Saeed1. 1. Sutton Eye Unit, Epsom and St. Helier University Hospitals, NHS Trust (Lead Clinician: Miss Jane Leitch), London, UK.
Abstract
BACKGROUND: The aim of this study was to investigate the clinical features and visual acuity outcomes associated with endogenous endophthalmitis. MATERIAL AND METHODS: Seven eyes of 6 patients treated at Epsom and St Helier University Hospitals between 2010 and 2013 were reviewed for endogenous endophthalmitis. RESULTS: Patients were followed for a mean of 7 months (range 1 to 13). Positive blood cultures were obtained in 5 patients (83%), including 1 patient with fungal isolates (17%), two patients with Gram-positive isolates and another two with Gram-negative isolates. Five patients (83%) were hospitalized at the time of diagnosis and 2 patients (33%) died within 6 months of diagnosis. Initial treatment included vitreous tap and injection of intravitreal antibiotics. Only in one eye (14%) were positive results from the biopsy obtained. Four eyes (57%) achieved a final visual acuity of >6/60. Patients with a Klebsiella endophthalmitis had worse visual outcome. CONCLUSIONS: Endogenous endophthalmitis is generally associated with high mortality and poor visual acuity outcomes. Gram-negative species are associated with poorer visual acuity. Vitreous biopsy has a weak diagnostic relevance as is it often negative. Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND: The aim of this study was to investigate the clinical features and visual acuity outcomes associated with endogenous endophthalmitis. MATERIAL AND METHODS: Seven eyes of 6 patients treated at Epsom and St Helier University Hospitals between 2010 and 2013 were reviewed for endogenous endophthalmitis. RESULTS:Patients were followed for a mean of 7 months (range 1 to 13). Positive blood cultures were obtained in 5 patients (83%), including 1 patient with fungal isolates (17%), two patients with Gram-positive isolates and another two with Gram-negative isolates. Five patients (83%) were hospitalized at the time of diagnosis and 2 patients (33%) died within 6 months of diagnosis. Initial treatment included vitreous tap and injection of intravitreal antibiotics. Only in one eye (14%) were positive results from the biopsy obtained. Four eyes (57%) achieved a final visual acuity of >6/60. Patients with a Klebsiella endophthalmitis had worse visual outcome. CONCLUSIONS: Endogenous endophthalmitis is generally associated with high mortality and poor visual acuity outcomes. Gram-negative species are associated with poorer visual acuity. Vitreous biopsy has a weak diagnostic relevance as is it often negative. Georg Thieme Verlag KG Stuttgart · New York.
Authors: Kathleen A Regan; Nila S Radhakrishnan; Jon D Hammer; Benjamin D Wilson; Lara Beth Gadkowski; Siva S R Iyer Journal: BMC Ophthalmol Date: 2020-04-07 Impact factor: 2.209