Literature DB >> 25900668

Synthesis of 2-(1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-ones from diaminoglyoxime-based nitrones.

Rahim Hosseinzadeh-Khanmiri1, Abolghasem Moghimi, Ahmad Shaabani, Hassan Valizadeh, Seik Weng Ng.   

Abstract

Various 2-[5-(aryl)-1,2,4-oxadiazol-3-yl]quinazolin-4(3H)-ones have been synthesized from the reaction of diaminoglyoxime-based nitrones with methyl 2-aminobenzoate or 2-aminobenzamide in the presence of acetic acid at 100 °C. The reaction was extended as a one-pot three-component approach starting from diaminoglyoxime, aldehyde and methyl 2-aminobenzoate.

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Year:  2015        PMID： 25900668     DOI： 10.1007/s11030-015-9588-0

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  25 in total

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Journal:  J Med Chem       Date:  2004-09-09       Impact factor: 7.446

4.  A novel isocyanide-based three-component reaction: synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives.

Authors:  Ahmad Shaabani; Ali Maleki; Jafar Moghimi-Rad
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5.  Synthesis and evaluation of substituted quinazolone derivatives for antibacterial, antifungal, and antiacetylcholinesterase activities.

Authors:  A K Gupta; H K Misra
Journal:  J Pharm Sci       Date:  1980-11       Impact factor: 3.534

6.  Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones.

Authors:  Demetrio Raffa; Michael C Edler; Giuseppe Daidone; Benedetta Maggio; Mourad Merikech; Mourad Merickech; Salvatore Plescia; Domenico Schillaci; Ruoli Bai; Ernest Hamel
Journal:  Eur J Med Chem       Date:  2004-04       Impact factor: 6.514

7.  Synthesis and evaluation of some novel quinazolinone derivatives as diuretic agents.

Authors:  Azza R Maarouf; Eman R El-Bendary; Fatma E Goda
Journal:  Arch Pharm (Weinheim)       Date:  2004-10       Impact factor: 3.751

8.  Synthesis and antihypertensive activity of novel 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones.

Authors:  Veerachamy Alagarsamy; Urvishbhai S Pathak
Journal:  Bioorg Med Chem       Date:  2007-03-06       Impact factor: 3.641

9.  Substituted quinazolines, part 2. Synthesis and in-vitro anticancer evaluation of new 2-substituted mercapto-3H-quinazoline analogs.

Authors:  Ashraf A Khalil; Sami G Abdel-Hamide; Abdulrahman M Al-Obaid; Hussein I El-Subbagh
Journal:  Arch Pharm (Weinheim)       Date:  2003-04       Impact factor: 3.751

10.  Design and synthesis of 3,5-disubstituted boron-containing 1,2,4-oxadiazoles as potential combretastatin A-4 (CA-4) analogs.

Authors:  Bhaskar C Das; Xiang-Ying Tang; Patrick Rogler; Todd Evans
Journal:  Tetrahedron Lett       Date:  2012-08-01       Impact factor: 2.415
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