Literature DB >> 17391966

Synthesis and antihypertensive activity of novel 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones.

Veerachamy Alagarsamy1, Urvishbhai S Pathak.   

Abstract

A series of 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones have been synthesized by the cyclocondensation of 3-amino-2-benzylamino-3H-quinazolin-4-one with a variety of one-carbon donors. The starting material 3-amino-2-benzylamino-3H-quinazolin-4-one was synthesized from methyl anthranilate by a novel innovative route. The title compounds were evaluated for their in vivo antihypertensive activity using spontaneously hypertensive rats (SHR). While all the test compounds exhibited significant antihypertensive activity, 3-benzyl-2-methyl-3H-[1,2,4]triazolo[5,1-b] quinazolin-9-one exhibited antihypertensive activity more than the reference standard prazocin.

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Year:  2007        PMID： 17391966     DOI： 10.1016/j.bmc.2007.03.007

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  15 in total

1.  Synthesis of 2-(1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-ones from diaminoglyoxime-based nitrones.

Authors:  Rahim Hosseinzadeh-Khanmiri; Abolghasem Moghimi; Ahmad Shaabani; Hassan Valizadeh; Seik Weng Ng
Journal:  Mol Divers       Date:  2015-04-22       Impact factor: 2.943

2.  Diaminoglyoxime as a versatile reagent in the synthesis of bis(1,2,4-oxadiazoles), 1,2,4-oxadiazolyl-quinazolines and 1,2,4-oxadiazolyl-benzothiazinones.

Authors:  Rahim Hosseinzadeh Khanmiri; Abolghasem Moghimi; Ahmad Shaabani; Hassan Valizadeh; Seik Weng Ng
Journal:  Mol Divers       Date:  2014-08-13       Impact factor: 2.943

3.  Ultrasound-promoted synthesis and immunosuppressive activity of novel quinazoline derivatives.

Authors:  Lei Zhang; Zhe Gao; Chen Peng; Zheng-Yang Bin; Dan Zhao; Jing Wu; Qiang Xu; Jian-Xin Li
Journal:  Mol Divers       Date:  2012-08-14       Impact factor: 2.943

4.  A three component one-pot procedure for the synthesis of [1,2,4]triazolo/benzimidazolo-quinazolinone derivatives in the presence of H6P2W18O(62).18H2O as a green and reusable catalyst.

Authors:  Majid M Heravi; Leila Ranjbar; Fatemeh Derikvand; Behnoush Alimadadi; Hossien A Oskooie; Fatemeh F Bamoharram
Journal:  Mol Divers       Date:  2008-09-09       Impact factor: 2.943

5.  Organocatalysis in heterocyclic synthesis: DABCO as a mild and efficient catalytic system for the synthesis of a novel class of quinazoline, thiazolo [3,2-a]quinazoline and thiazolo[2,3-b] quinazoline derivatives.

Authors:  Haider Behbehani; Hamada Mohamed Ibrahim
Journal:  Chem Cent J       Date:  2013-05-07       Impact factor: 4.215

6.  Diversity oriented one-pot three-component sequential synthesis of annulated benzothiazoloquinazolines.

Authors:  Mahendra Kumar; Kailash Sharma; Dinesh Kumar Sharma
Journal:  Org Med Chem Lett       Date:  2012-03-02

Review 7.  Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Authors:  Mohammad Asif
Journal:  Int J Med Chem       Date:  2014-11-12

8.  Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure.

Authors:  Rashad Al-Salahi; Kamal-Eldin El-Tahir; Ibrahim Alswaidan; Nabih Lolak; Mohammed Hamidaddin; Mohamed Marzouk
Journal:  Chem Cent J       Date:  2014-01-15       Impact factor: 4.215

9.  Synthesis and antihypertensive screening of new derivatives of quinazolines linked with isoxazole.

Authors:  Mujeeb Ur Rahman; Ankita Rathore; Anees A Siddiqui; Gazala Parveen; M Shahar Yar
Journal:  Biomed Res Int       Date:  2014-06-12       Impact factor: 3.411

10.  Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents.

Authors:  Walaa S El-Serwy; Neama A Mohamed; Emad M M Kassem; Khaled Mahmoud; M M Mounier
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696
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