OBJECTIVES: To determine life expectancy for older women with breast cancer. DESIGN: Prospective longitudinal study with 10 years of follow-up data. SETTING: Hospitals or collaborating tumor registries in four geographic regions (Los Angeles, California; Minnesota; North Carolina; Rhode Island). PARTICIPANTS: Women aged 65 and older at time of breast cancer diagnosis with Stage I to IIIA disease with measures of self-rated health (SRH) and walking ability at baseline (N = 615; 17% aged ≥80, 52% Stage I, 58% with ≥2 comorbidities). MEASUREMENTS: Baseline SRH, baseline self-reported walking ability, all-cause and breast cancer-specific estimated probability of 5- and 10-year survival. RESULTS: At the time of breast cancer diagnosis, 39% of women reported poor SRH, and 28% reported limited ability to walk several blocks. The all-cause survival curves appear to separate after approximately 3 years, and the difference in survival probability between those with low SRH and limited walking ability and those with high SRH and no walking ability limitation was significant (0.708 vs 0.855 at 5 years, P ≤ .001; 0.300 vs 0.648 at 10 years, P < .001). There were no differences between the groups in breast cancer-specific survival at 5 and 10 years (P = .66 at 5 years, P = .16 at 10 years). CONCLUSION: The combination of low SRH and limited ability to walk several blocks at diagnosis is an important predictor of worse all-cause survival at 5 and 10 years. These self-report measures easily assessed in clinical practice may be an effective strategy to improve treatment decision-making in older adults with cancer.
OBJECTIVES: To determine life expectancy for older women with breast cancer. DESIGN: Prospective longitudinal study with 10 years of follow-up data. SETTING: Hospitals or collaborating tumor registries in four geographic regions (Los Angeles, California; Minnesota; North Carolina; Rhode Island). PARTICIPANTS: Women aged 65 and older at time of breast cancer diagnosis with Stage I to IIIA disease with measures of self-rated health (SRH) and walking ability at baseline (N = 615; 17% aged ≥80, 52% Stage I, 58% with ≥2 comorbidities). MEASUREMENTS: Baseline SRH, baseline self-reported walking ability, all-cause and breast cancer-specific estimated probability of 5- and 10-year survival. RESULTS: At the time of breast cancer diagnosis, 39% of women reported poor SRH, and 28% reported limited ability to walk several blocks. The all-cause survival curves appear to separate after approximately 3 years, and the difference in survival probability between those with low SRH and limited walking ability and those with high SRH and no walking ability limitation was significant (0.708 vs 0.855 at 5 years, P ≤ .001; 0.300 vs 0.648 at 10 years, P < .001). There were no differences between the groups in breast cancer-specific survival at 5 and 10 years (P = .66 at 5 years, P = .16 at 10 years). CONCLUSION: The combination of low SRH and limited ability to walk several blocks at diagnosis is an important predictor of worse all-cause survival at 5 and 10 years. These self-report measures easily assessed in clinical practice may be an effective strategy to improve treatment decision-making in older adults with cancer.
Authors: F Efficace; L Biganzoli; M Piccart; C Coens; K Van Steen; T Cufer; R E Coleman; H A Calvert; T Gamucci; C Twelves; P Fargeot; A Bottomley Journal: Eur J Cancer Date: 2004-05 Impact factor: 9.162
Authors: Arti Hurria; Ilene S Browner; Harvey Jay Cohen; Crystal S Denlinger; Mollie deShazo; Martine Extermann; Apar Kishor P Ganti; Jimmie C Holland; Holly M Holmes; Mohana B Karlekar; Nancy L Keating; June McKoy; Bruno C Medeiros; Ewa Mrozek; Tracey O'Connor; Stephen H Petersdorf; Hope S Rugo; Rebecca A Silliman; William P Tew; Louise C Walter; Alva B Weir; Tanya Wildes Journal: J Natl Compr Canc Netw Date: 2012-02 Impact factor: 11.908
Authors: Supriya Gupta Mohile; Ying Xian; William Dale; Susan G Fisher; Miriam Rodin; Gary R Morrow; Alfred Neugut; William Hall Journal: J Natl Cancer Inst Date: 2009-07-28 Impact factor: 13.506
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: Lillian Min; William Yoon; Jeff Mariano; Neil S Wenger; Marc N Elliott; Caren Kamberg; Debra Saliba Journal: J Am Geriatr Soc Date: 2009-09-28 Impact factor: 5.562
Authors: Clark Dumontier; Kerri M Clough-Gorr; Rebecca A Silliman; Andreas E Stuck; André Moser Journal: J Geriatr Oncol Date: 2016-12-13 Impact factor: 3.599
Authors: Lidvine Godaert; C Godard-Sebillotte; L Allard Saint-Albin; L Bousquet; I Bourdel-Marchasson; J-L Fanon; M Dramé Journal: Qual Life Res Date: 2017-09-01 Impact factor: 4.147
Authors: Jeanne S Mandelblatt; Ling Cai; George Luta; Gretchen Kimmick; Jonathan Clapp; Claudine Isaacs; Brandeyln Pitcher; William Barry; Eric Winer; Stephen Sugarman; Clifford Hudis; Hyman Muss; Harvey J Cohen; Arti Hurria Journal: Breast Cancer Res Treat Date: 2017-03-31 Impact factor: 4.872
Authors: Smith Giri; Nabiel Mir; Mustafa Al-Obaidi; Deanna Clark; Kelly M Kenzik; Andrew McDonald; Crystal Young-Smith; Ravi Paluri; Lakshmin Nandagopal; Olumide Gbolahan; Kirsten A Nyrop; Hyman B Muss; Mackenzi Pergolotti; Smita Bhatia; Grant R Williams Journal: Oncologist Date: 2022-02-03 Impact factor: 5.837