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Literature DB >> 2589848

Treatment of experimental disseminated candidiasis with cilofungin.

J R Perfect¹, M M Hobbs, K A Wright, D T Durack.

Abstract

The efficacy of cilofungin treatment of experimental disseminated candidiasis in rabbits was examined. Cilofungin treatment reduced yeast counts, especially in the kidney, with activity comparable to that of amphotericin B. The peak level of cilofungin in serum was measured at 5 min after administration of a single dose, with no drug detectable after 90 min.

Entities: Chemical Disease Species

Mesh：

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Year: 1989 PMID： 2589848 PMCID： PMC172760 DOI： 10.1128/AAC.33.10.1811

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. Evaluation of in vitro antifungal activity of LY121019.

Authors: M Hobbs; J Perfect; D Durack
Journal: Eur J Clin Microbiol Infect Dis Date: 1988-02 Impact factor: 3.267

2. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.

Authors: J R Perfect; D V Savani; D T Durack
Journal: Antimicrob Agents Chemother Date: 1986-04 Impact factor: 5.191

3. In vitro and in vivo anti-Candida activity and toxicology of LY121019.

Authors: R S Gordee; D J Zeckner; L F Ellis; A L Thakkar; L C Howard
Journal: J Antibiot (Tokyo) Date: 1984-09 Impact factor: 2.649

4. Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis.

Authors: J R Perfect; D T Durack
Journal: Antimicrob Agents Chemother Date: 1985-12 Impact factor: 5.191

5. Comparative in vitro activity of LY121019 and amphotericin B against clinical isolates of Candida species.

Authors: E D Spitzer; S J Travis; G S Kobayashi
Journal: Eur J Clin Microbiol Infect Dis Date: 1988-02 Impact factor: 3.267

5 in total

12 in total

1. Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits.

Authors: J W Lee; P Kelly; J Lecciones; D Coleman; R Gordee; P A Pizzo; T J Walsh
Journal: Antimicrob Agents Chemother Date: 1990-11 Impact factor: 5.191

2. Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemic Candida albicans infection in the neutropenic mouse.

Authors: R M Bannatyne; P C Cheng; I W Fong
Journal: Infection Date: 1992 May-Jun Impact factor: 3.553

3. Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits.

Authors: M S Rouse; B M Tallan; J M Steckelberg; N K Henry; W R Wilson
Journal: Antimicrob Agents Chemother Date: 1992-01 Impact factor: 5.191

4. Evaluation of a murine model of hepatic candidiasis.

Authors: G T Cole; K T Lynn; K R Seshan
Journal: J Clin Microbiol Date: 1990-08 Impact factor: 5.948

5. In vitro activity of the new semi-synthetic polypeptide cilofungin (LY121019) against Aspergillus and Candida species.

Authors: A Huang; F Edwards; E M Bernard; D Armstrong; H J Schmitt
Journal: Eur J Clin Microbiol Infect Dis Date: 1990-09 Impact factor: 3.267

6. Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.

Authors: K R Smith; K M Lank; C G Cobbs; G A Cloud; W E Dismukes
Journal: Antimicrob Agents Chemother Date: 1990-08 Impact factor: 5.191

7. Comparative efficacies of cilofungin (Ly121019) and amphotericin B against disseminated Candida albicans infection in normal and granulocytopenic mice.

Authors: N Khardori; H Nguyen; L C Stephens; L Kalvakuntla; B Rosenbaum; G P Bodey
Journal: Antimicrob Agents Chemother Date: 1993-04 Impact factor: 5.191

8. Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis.

Authors: D W Denning; D A Stevens
Journal: Antimicrob Agents Chemother Date: 1991-07 Impact factor: 5.191

9. Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.

Authors: T J Walsh; J W Lee; P Kelly; J Bacher; J Lecciones; V Thomas; C Lyman; D Coleman; R Gordee; P A Pizzo
Journal: Antimicrob Agents Chemother Date: 1991-07 Impact factor: 5.191

10. In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates of Candida species.

Authors: K R Smith; K M Lank; W E Dismukes; C G Cobbs
Journal: Eur J Clin Microbiol Infect Dis Date: 1991-07 Impact factor: 3.267