Literature DB >> 2221875

Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.

K R Smith1, K M Lank, C G Cobbs, G A Cloud, W E Dismukes.   

Abstract

We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P less than 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2221875      PMCID： PMC171887          DOI： 10.1128/AAC.34.8.1619

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Anti-Candida activity and toxicology of LY121019, a novel semisynthetic polypeptide antifungal antibiotic.

Authors:  R S Gordee; D J Zeckner; L C Howard; W E Alborn; M Debono
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

2.  Susceptibility of nosocomial isolates of Candida species to LY121019 and other antifungal agents.

Authors:  M A Pfaller; S Wey; T Gerarden; A Houston; R P Wenzel
Journal:  Diagn Microbiol Infect Dis       Date:  1989 Jan-Feb       Impact factor: 2.803

3.  Evaluation of in vitro antifungal activity of LY121019.

Authors:  M Hobbs; J Perfect; D Durack
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1988-02       Impact factor: 3.267

4.  Cilofungin (LY121019), an antifungal agent with specific activity against Candida albicans and Candida tropicalis.

Authors:  G S Hall; C Myles; K J Pratt; J A Washington
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

5.  In vitro and in vivo anti-Candida activity and toxicology of LY121019.

Authors:  R S Gordee; D J Zeckner; L F Ellis; A L Thakkar; L C Howard
Journal:  J Antibiot (Tokyo)       Date:  1984-09       Impact factor: 2.649

6.  Echinocandin inhibition of 1,3-beta-D-glucan synthase from Candida albicans.

Authors:  E T Sawistowska-Schröder; D Kerridge; H Perry
Journal:  FEBS Lett       Date:  1984-07-23       Impact factor: 4.124

7.  Comparative in vitro activity of LY121019 and amphotericin B against clinical isolates of Candida species.

Authors:  E D Spitzer; S J Travis; G S Kobayashi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1988-02       Impact factor: 3.267

8.  pH and other effects on the antifungal activity of cilofungin (LY121019).

Authors:  K A McIntyre; J N Galgiani
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

9.  Evaluation of cilofungin (LY121019) for treatment of experimental Candida albicans endocarditis in rabbits.

Authors:  A Padula; H F Chambers
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

10.  Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity.

Authors:  C S Taft; T Stark; C P Selitrennikoff
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191
View more
  6 in total

1.  Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemic Candida albicans infection in the neutropenic mouse.

Authors:  R M Bannatyne; P C Cheng; I W Fong
Journal:  Infection       Date:  1992 May-Jun       Impact factor: 3.553

2.  Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits.

Authors:  M S Rouse; B M Tallan; J M Steckelberg; N K Henry; W R Wilson
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

Review 3.  Compounds active against cell walls of medically important fungi.

Authors:  R F Hector
Journal:  Clin Microbiol Rev       Date:  1993-01       Impact factor: 26.132

4.  Comparative efficacies of cilofungin (Ly121019) and amphotericin B against disseminated Candida albicans infection in normal and granulocytopenic mice.

Authors:  N Khardori; H Nguyen; L C Stephens; L Kalvakuntla; B Rosenbaum; G P Bodey
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

5.  In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates of Candida species.

Authors:  K R Smith; K M Lank; W E Dismukes; C G Cobbs
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-07       Impact factor: 3.267

6.  Treatment of murine invasive candidiasis with amphotericin B and cilofungin: evidence for enhanced activity with combination therapy.

Authors:  A M Sugar; L Z Goldani; M Picard
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.