Literature DB >> 25894419

Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase.

Jingming Zhao1, Anna Kajetanowicz, Thomas R Ward.   

Abstract

An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.

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Year:  2015        PMID： 25894419     DOI： 10.1039/c5ob00428d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  7 in total

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Journal:  Chem Rev       Date:  2017-07-21       Impact factor: 60.622

2.  Artificial Diels-Alderase based on the transmembrane protein FhuA.

Authors:  Hassan Osseili; Daniel F Sauer; Klaus Beckerle; Marcus Arlt; Tomoki Himiyama; Tino Polen; Akira Onoda; Ulrich Schwaneberg; Takashi Hayashi; Jun Okuda
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Review 3.  Artificial Metalloenzymes: Challenges and Opportunities.

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Journal:  ACS Cent Sci       Date:  2019-07-16       Impact factor: 14.553

4.  Atroposelective antibodies as a designed protein scaffold for artificial metalloenzymes.

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Journal:  Sci Rep       Date:  2019-09-19       Impact factor: 4.379

Review 5.  Unlocking the therapeutic potential of artificial metalloenzymes.

Authors:  Katsunori Tanaka; Kenward Vong
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2020       Impact factor: 3.493

6.  Engineering a Metathesis-Catalyzing Artificial Metalloenzyme Based on HaloTag.

Authors:  Sandro Fischer; Thomas R Ward; Alexandria D Liang
Journal:  ACS Catal       Date:  2021-05-12       Impact factor: 13.084

7.  It is Better with Salt: Aqueous Ring-Opening Metathesis Polymerization at Neutral pH.

Authors:  Jeffrey C Foster; Marcus C Grocott; Lucy A Arkinstall; Spyridon Varlas; McKenna J Redding; Scott M Grayson; Rachel K O'Reilly
Journal:  J Am Chem Soc       Date:  2020-08-03       Impact factor: 15.419
  7 in total

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