| Literature DB >> 25893388 |
Mehdi Shafiee Ardestani1, Alireza Salehi Fordoei, Asghar Abdoli, Reza Ahangari Cohan, Golnaz Bahramali, Seyed Mehdi Sadat, Seyed Davar Siadat, Hamid Moloudian, Nasser Nassiri Koopaei, Azam Bolhasani, Pooneh Rahimi, Soheila Hekmat, Mehdi Davari, Mohammad Reza Aghasadeghi.
Abstract
HIV is commonly caused to a very complicated disease which has not any recognized vaccine, so designing and development of novel antiretroviral agents with specific application of nanomedicine is a globally interested research subject worldwide. In the current study, a novel structure of silver complexes with anionic linear globular dendrimer was synthesized, characterized and then assessed against HIV replication pathway in vitro as well. The results showed a very good yield of synthesis (up to 70%) for the nano-complex as well as a very potent significant (P < 0.05) antiretroviral activity with non-severe toxic effects in comparison with the Nevirapine as standard drug in positive control group. According to the present data, silver anionic linear globular dendrimers complex may have a promising future to inhibit replication of HIV viruse in clinical practice.Entities:
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Year: 2015 PMID： 25893388 DOI： 10.1007/s10856-015-5510-7
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 4.727