Literature DB >> 18538887

Multi-functional nanocarriers for targeted delivery of drugs and genes.

Lara Jabr-Milane1, Lilian van Vlerken, Harikrishna Devalapally, Dinesh Shenoy, Sushma Komareddy, Mayank Bhavsar, Mansoor Amiji.   

Abstract

In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platforms that offer opportunities for multi-functionalization to allow for targeted stimuli-responsive and/or simultaneous strategic delivery of multiple drugs, genes, as well as the combination of therapeutic systems with image contrast enhancers. Polymeric and lipid-based nanocarriers can provide versatile platforms for the delivery of multiple pharmacological agents, specifically to enhance therapeutic effect and overcome drug resistance in cancer. In addition, polymeric nanoparticles and nanoparticles-in-microsphere oral system (NiMOS) are useful for systemic and oral gene therapy, respectively.

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Year:  2008        PMID： 18538887     DOI： 10.1016/j.jconrel.2008.04.016

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  22 in total

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Journal:  Drug Discov Today       Date:  2011-03-23       Impact factor: 7.851

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Journal:  Drug Deliv Transl Res       Date:  2013-10       Impact factor: 4.617

Review 5.  Nanomedicine associated with photodynamic therapy for glioblastoma treatment.

Authors:  Leonardo B de Paula; Fernando L Primo; Antonio C Tedesco
Journal:  Biophys Rev       Date:  2017-08-19

6.  Formulation development and process parameter optimization of lipid nanoemulsions using an alginate-protein stabilizer.

Authors:  Surashree Sen Gupta; Mahua Ghosh
Journal:  J Food Sci Technol       Date:  2014-04-23       Impact factor: 2.701

7.  Novel pentablock copolymers for selective gene delivery to cancer cells.

Authors:  Bingqi Zhang; Mathumai Kanapathipillai; Paul Bisso; Surya Mallapragada
Journal:  Pharm Res       Date:  2009-01-14       Impact factor: 4.200

8.  Microscopy and tunable resistive pulse sensing characterization of the swelling of pH-responsive, polymeric expansile nanoparticles.

Authors:  Aaron H Colby; Yolonda L Colson; Mark W Grinstaff
Journal:  Nanoscale       Date:  2013-03-13       Impact factor: 7.790

9.  Label-Free Raman Microspectral Analysis for Comparison of Cellular Uptake and Distribution between Non-Targeted and EGFR-Targeted Biodegradable Polymeric Nanoparticles.

Authors:  Tatyana Chernenko; Fulden Buyukozturk; Milos Miljkovic; Rebecca Carrier; Max Diem; Mansoor Amiji
Journal:  Drug Deliv Transl Res       Date:  2013-12-01       Impact factor: 4.617

10.  Synthetically programmable DNA binding domains in aggregates of DNA-functionalized gold nanoparticles.

Authors:  Sarah J Hurst; Haley D Hill; Robert J Macfarlane; Jinsong Wu; Vinayak P Dravid; Chad A Mirkin
Journal:  Small       Date:  2009-10       Impact factor: 13.281
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