Literature DB >> 25891142

Antimalarial drug resistance in Africa: key lessons for the future.

Shannon Takala-Harrison1, Miriam K Laufer.   

Abstract

Drug-resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs and have contributed significantly to the failure to control and eradicate malaria throughout the world. In this review, we describe the spread of resistance to chloroquine and sulfadoxine-pyrimethamine, two old drugs that are no longer used owing to high rates of resistance, and examine the effect of the removal of drug pressure on the survival of resistant parasites. Artemisinin-resistant malaria is now emerging in Southeast Asia in a unique and unexpected pattern. We will review the most recent genomic and clinical data to help predict the behavior of resistance to new antimalarial medications and inform strategies to prevent the spread of drug-resistant malaria in Africa in the future.
© 2015 New York Academy of Sciences.

Entities:  

Keywords:  Africa; artemisinin resistance; artemisinin-based combination therapy; drug resistance; malaria; molecular epidemiology

Mesh：

Substances：

Year:  2015        PMID： 25891142      PMCID： PMC4527866          DOI： 10.1111/nyas.12766

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  44 in total

1.  Evidence of artemisinin-resistant malaria in western Cambodia.

Authors:  Harald Noedl; Youry Se; Kurt Schaecher; Bryan L Smith; Duong Socheat; Mark M Fukuda
Journal:  N Engl J Med       Date:  2008-12-08       Impact factor: 91.245

2.  A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

Authors:  Frédéric Ariey; Benoit Witkowski; Chanaki Amaratunga; Johann Beghain; Anne-Claire Langlois; Nimol Khim; Saorin Kim; Valentine Duru; Christiane Bouchier; Laurence Ma; Pharath Lim; Rithea Leang; Socheat Duong; Sokunthea Sreng; Seila Suon; Char Meng Chuor; Denis Mey Bout; Sandie Ménard; William O Rogers; Blaise Genton; Thierry Fandeur; Olivo Miotto; Pascal Ringwald; Jacques Le Bras; Antoine Berry; Jean-Christophe Barale; Rick M Fairhurst; Françoise Benoit-Vical; Odile Mercereau-Puijalon; Didier Ménard
Journal:  Nature       Date:  2013-12-18       Impact factor: 49.962

3.  Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

Authors:  L K Basco; P Eldin de Pécoulas; C M Wilson; J Le Bras; A Mazabraud
Journal:  Mol Biochem Parasitol       Date:  1995-01       Impact factor: 1.759

4.  A major genome region underlying artemisinin resistance in malaria.

Authors:  Ian H Cheeseman; Becky A Miller; Shalini Nair; Standwell Nkhoma; Asako Tan; John C Tan; Salma Al Saai; Aung Pyae Phyo; Carit Ler Moo; Khin Maung Lwin; Rose McGready; Elizabeth Ashley; Mallika Imwong; Kasia Stepniewska; Poravuth Yi; Arjen M Dondorp; Mayfong Mayxay; Paul N Newton; Nicholas J White; François Nosten; Michael T Ferdig; Timothy J C Anderson
Journal:  Science       Date:  2012-04-06       Impact factor: 47.728

5.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

6.  Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa.

Authors:  C V Plowe; A Djimde; M Bouare; O Doumbo; T E Wellems
Journal:  Am J Trop Med Hyg       Date:  1995-06       Impact factor: 2.345

7.  Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Elizabeth A Ashley; Mehul Dhorda; Rick M Fairhurst; Chanaki Amaratunga; Parath Lim; Seila Suon; Sokunthea Sreng; Jennifer M Anderson; Sivanna Mao; Baramey Sam; Chantha Sopha; Char Meng Chuor; Chea Nguon; Siv Sovannaroth; Sasithon Pukrittayakamee; Podjanee Jittamala; Kesinee Chotivanich; Kitipumi Chutasmit; Chaiyaporn Suchatsoonthorn; Ratchadaporn Runcharoen; Tran Tinh Hien; Nguyen Thanh Thuy-Nhien; Ngo Viet Thanh; Nguyen Hoan Phu; Ye Htut; Kay-Thwe Han; Kyin Hla Aye; Olugbenga A Mokuolu; Rasaq R Olaosebikan; Olaleke O Folaranmi; Mayfong Mayxay; Maniphone Khanthavong; Bouasy Hongvanthong; Paul N Newton; Marie A Onyamboko; Caterina I Fanello; Antoinette K Tshefu; Neelima Mishra; Neena Valecha; Aung Pyae Phyo; Francois Nosten; Poravuth Yi; Rupam Tripura; Steffen Borrmann; Mahfudh Bashraheil; Judy Peshu; M Abul Faiz; Aniruddha Ghose; M Amir Hossain; Rasheda Samad; M Ridwanur Rahman; M Mahtabuddin Hasan; Akhterul Islam; Olivo Miotto; Roberto Amato; Bronwyn MacInnis; Jim Stalker; Dominic P Kwiatkowski; Zbynek Bozdech; Atthanee Jeeyapant; Phaik Yeong Cheah; Tharisara Sakulthaew; Jeremy Chalk; Benjamas Intharabut; Kamolrat Silamut; Sue J Lee; Benchawan Vihokhern; Chanon Kunasol; Mallika Imwong; Joel Tarning; Walter J Taylor; Shunmay Yeung; Charles J Woodrow; Jennifer A Flegg; Debashish Das; Jeffery Smith; Meera Venkatesan; Christopher V Plowe; Kasia Stepniewska; Philippe J Guerin; Arjen M Dondorp; Nicholas P Day; Nicholas J White
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

8.  Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.

Authors:  Steffen Borrmann; Philip Sasi; Leah Mwai; Mahfudh Bashraheil; Ahmed Abdallah; Steven Muriithi; Henrike Frühauf; Barbara Schaub; Johannes Pfeil; Judy Peshu; Warunee Hanpithakpong; Anja Rippert; Elizabeth Juma; Benjamin Tsofa; Moses Mosobo; Brett Lowe; Faith Osier; Greg Fegan; Niklas Lindegårdh; Alexis Nzila; Norbert Peshu; Margaret Mackinnon; Kevin Marsh
Journal:  PLoS One       Date:  2011-11-10       Impact factor: 3.240

9.  Low Prevalence of Pfcrt Resistance Alleles among Patients with Uncomplicated Falciparum Malaria in Niger Six Years after Chloroquine Withdrawal.

Authors:  Adamou Salissou; Halima Zamanka; Brigitte Biyghe Binze; Taiana Rivière; Magalie Tichit; Maman Laminou Ibrahim; Thierry Fandeur
Journal:  Malar Res Treat       Date:  2014-11-23

10.  Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.

Authors:  Jianbing Mu; Rachel A Myers; Hongying Jiang; Shengfa Liu; Stacy Ricklefs; Michael Waisberg; Kesinee Chotivanich; Polrat Wilairatana; Srivicha Krudsood; Nicholas J White; Rachanee Udomsangpetch; Liwang Cui; May Ho; Fengzhen Ou; Haibo Li; Jianping Song; Guoqiao Li; Xinhua Wang; Suon Seila; Sreng Sokunthea; Duong Socheat; Daniel E Sturdevant; Stephen F Porcella; Rick M Fairhurst; Thomas E Wellems; Philip Awadalla; Xin-zhuan Su
Journal:  Nat Genet       Date:  2010-01-31       Impact factor: 38.330
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  37 in total

Review 1.  Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.

Authors:  Benjamin Blasco; Didier Leroy; David A Fidock
Journal:  Nat Med       Date:  2017-08-04       Impact factor: 53.440

Review 2.  Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.

Authors:  Leila S Ross; David A Fidock
Journal:  Cell Host Microbe       Date:  2019-07-10       Impact factor: 21.023

3.  UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Authors:  Christel Brunschwig; Nina Lawrence; Dale Taylor; Efrem Abay; Mathew Njoroge; Gregory S Basarab; Claire Le Manach; Tanya Paquet; Diego Gonzàlez Cabrera; Aloysius T Nchinda; Carmen de Kock; Lubbe Wiesner; Paolo Denti; David Waterson; Benjamin Blasco; Didier Leroy; Michael J Witty; Cristina Donini; James Duffy; Sergio Wittlin; Karen L White; Susan A Charman; Maria Belén Jiménez-Díaz; Iñigo Angulo-Barturen; Esperanza Herreros; Francisco Javier Gamo; Rosemary Rochford; Dalu Mancama; Theresa L Coetzer; Mariëtte E van der Watt; Janette Reader; Lyn-Marie Birkholtz; Kennan C Marsh; Suresh M Solapure; John E Burke; Jacob A McPhail; Manu Vanaerschot; David A Fidock; Paul V Fish; Peter Siegl; Dennis A Smith; Grennady Wirjanata; Rintis Noviyanti; Ric N Price; Jutta Marfurt; Kigbafori D Silue; Leslie J Street; Kelly Chibale
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

4.  In Vitro and Molecular Surveillance for Antimalarial Drug Resistance in Plasmodium falciparum Parasites in Western Kenya Reveals Sustained Artemisinin Sensitivity and Increased Chloroquine Sensitivity.

Authors:  Naomi W Lucchi; Franklin Komino; Sheila Akinyi Okoth; Ira Goldman; Philip Onyona; Ryan E Wiegand; Elizabeth Juma; Ya Ping Shi; John W Barnwell; Venkatachalam Udhayakumar; Simon Kariuki
Journal:  Antimicrob Agents Chemother       Date:  2015-09-21       Impact factor: 5.191

5.  Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity.

Authors:  Hangjun Ke; Joanne M Morrisey; Shiwei Qu; Oraphin Chantarasriwong; Michael W Mather; Emmanuel A Theodorakis; Akhil B Vaidya
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

Review 6.  Antimalarial Drug Resistance: A Threat to Malaria Elimination.

Authors:  Didier Menard; Arjen Dondorp
Journal:  Cold Spring Harb Perspect Med       Date:  2017-07-05       Impact factor: 6.915

7.  Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Authors:  Tanya Paquet; Claire Le Manach; Diego González Cabrera; Yassir Younis; Philipp P Henrich; Tara S Abraham; Marcus C S Lee; Rajshekhar Basak; Sonja Ghidelli-Disse; María José Lafuente-Monasterio; Marcus Bantscheff; Andrea Ruecker; Andrew M Blagborough; Sara E Zakutansky; Anne-Marie Zeeman; Karen L White; David M Shackleford; Janne Mannila; Julia Morizzi; Christian Scheurer; Iñigo Angulo-Barturen; María Santos Martínez; Santiago Ferrer; Laura María Sanz; Francisco Javier Gamo; Janette Reader; Mariette Botha; Koen J Dechering; Robert W Sauerwein; Anchalee Tungtaeng; Pattaraporn Vanachayangkul; Chek Shik Lim; Jeremy Burrows; Michael J Witty; Kennan C Marsh; Christophe Bodenreider; Rosemary Rochford; Suresh M Solapure; María Belén Jiménez-Díaz; Sergio Wittlin; Susan A Charman; Cristina Donini; Brice Campo; Lyn-Marie Birkholtz; Kirsten K Hanson; Gerard Drewes; Clemens H M Kocken; Michael J Delves; Didier Leroy; David A Fidock; David Waterson; Leslie J Street; Kelly Chibale
Journal:  Sci Transl Med       Date:  2017-04-26       Impact factor: 17.956

8.  Combating Malaria: Where do We Stand?

Authors:  Mamie T Coats
Journal:  J Infect Dis Ther       Date:  2016-02-19

Review 9.  Targeting autophagy to sensitive glioma to temozolomide treatment.

Authors:  Yuanliang Yan; Zhijie Xu; Shuang Dai; Long Qian; Lunquan Sun; Zhicheng Gong
Journal:  J Exp Clin Cancer Res       Date:  2016-02-02

10.  Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

Authors:  M Isabel Veiga; Satish K Dhingra; Philipp P Henrich; Judith Straimer; Nina Gnädig; Anne-Catrin Uhlemann; Rowena E Martin; Adele M Lehane; David A Fidock
Journal:  Nat Commun       Date:  2016-05-18       Impact factor: 14.919
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