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Literature DB >> 25877200

A resource for cell line authentication, annotation and quality control.

Mamie Yu¹, Suresh K Selvaraj¹, May M Y Liang-Chu¹, Sahar Aghajani², Matthew Busse², Jean Yuan², Genee Lee¹, Franklin Peale³, Christiaan Klijn², Richard Bourgon², Joshua S Kaminker², Richard M Neve¹.

Abstract

Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.

Mesh：

Year: 2015 PMID： 25877200 DOI： 10.1038/nature14397

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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9. SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.

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