Li-An Wu1,2, Ruey-Feng Chang3, Chiun-Sheng Huang4, Yen-Shen Lu5, Hong-Hao Chen3, Jo-Yu Chen1, Yeun-Chung Chang1. 1. Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 2. Department of Medical Imaging, Taipei City Hospital, Heping, Branch, Taipei, Taiwan. 3. Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan. 4. Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 5. Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Abstract
PURPOSE: To evaluate the treatment response of locally advanced breast cancer (LABC) to neoadjuvant chemotherapy using magnetic resonance (MR) vascular maps and apparent diffusion coefficient (ADC) at 3T. Materials and Methods Thirty-one patients with LABC who underwent breast MR studies before, after the first course, and after completing neoadjuvant chemotherapy were enrolled. Vascular morphology was retrieved via Hessian matrix and the voxels of the vessels and volume of vessels were measured automatically. Whole tumor mean ADC values were calculated. Clinical responders were defined as >50% tumor reduction in the final MR studies. Pathologically complete responders were also recorded. RESULTS: There were 21 clinical responders and 10 nonresponders. Compared to the nonresponders after the first course, the responders were characterized by more vascular reduction of the breast lesion and decreased bilateral vascular discrepancy (voxels and volume), and increments in the ADC value and ADC percentage of the lesions (all P < 0.05). There were three pathological complete responders who showed more apparent early vascular reduction of the lesion breast (voxels and volume) and increments in the ADC value than others (P = 0.02, 0.01 and 0.02, respectively). CONCLUSION: The early changes of MR vascular maps and ADC are associated with the final treatment response of LABC.
PURPOSE: To evaluate the treatment response of locally advanced breast cancer (LABC) to neoadjuvant chemotherapy using magnetic resonance (MR) vascular maps and apparent diffusion coefficient (ADC) at 3T. Materials and Methods Thirty-one patients with LABC who underwent breast MR studies before, after the first course, and after completing neoadjuvant chemotherapy were enrolled. Vascular morphology was retrieved via Hessian matrix and the voxels of the vessels and volume of vessels were measured automatically. Whole tumor mean ADC values were calculated. Clinical responders were defined as >50% tumor reduction in the final MR studies. Pathologically complete responders were also recorded. RESULTS: There were 21 clinical responders and 10 nonresponders. Compared to the nonresponders after the first course, the responders were characterized by more vascular reduction of the breast lesion and decreased bilateral vascular discrepancy (voxels and volume), and increments in the ADC value and ADC percentage of the lesions (all P < 0.05). There were three pathological complete responders who showed more apparent early vascular reduction of the lesion breast (voxels and volume) and increments in the ADC value than others (P = 0.02, 0.01 and 0.02, respectively). CONCLUSION: The early changes of MR vascular maps and ADC are associated with the final treatment response of LABC.
Authors: John Virostko; Allison Hainline; Hakmook Kang; Lori R Arlinghaus; Richard G Abramson; Stephanie L Barnes; Jeffrey D Blume; Sarah Avery; Debra Patt; Boone Goodgame; Thomas E Yankeelov; Anna G Sorace Journal: J Med Imaging (Bellingham) Date: 2017-11-24
Authors: John Virostko; Anna G Sorace; Chengyue Wu; David Ekrut; Angela M Jarrett; Raghave M Upadhyaya; Sarah Avery; Debra Patt; Boone Goodgame; Thomas E Yankeelov Journal: Tomography Date: 2019-03