Literature DB >> 25873316

Determination of trimethylamine-N-oxide in combination with L-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS.

Solveiga Grinberga1, Maija Dambrova1,2, Gustavs Latkovskis3,4,5, Ieva Strele2, Ilze Konrade2, Dace Hartmane1, Eduards Sevostjanovs1,4, Edgars Liepinsh1, Osvalds Pugovics1.   

Abstract

An ultra-high-performance liquid chromatography-mass spectrometry (UPLC/MS/MS) method was developed and validated for the quantification of trimethylamine-N-oxide (TMAO) simultaneously with TMAO-related molecules L-carnitine and γ-butyrobetaine (GBB) in human blood plasma. The separation of analytes was achieved using a Hydrophilic interaction liquid chromatography (HILIC)-type column with ammonium acetate-acetonitrile as the mobile phase. TMAO determination was validated according to valid US Food and Drug Administration guidelines. The developed method was successfully applied to plasma samples from healthy volunteers.
Copyright © 2015 John Wiley & Sons, Ltd.

Entities:  

Keywords:  UPLC/MS/MS; human plasma; l-carnitine; trimethylamine N-oxide; γ-butyrobetaine

Mesh：

Substances：

Year:  2015        PMID： 25873316     DOI： 10.1002/bmc.3477

Source DB:  PubMed          Journal:  Biomed Chromatogr        ISSN： 0269-3879            Impact factor:   1.902


  8 in total

1.  Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine-N-oxide.

Authors:  G Latkovskis; E Makarova; M Mazule; L Bondare; D Hartmane; H Cirule; S Grinberga; A Erglis; E Liepinsh; M Dambrova
Journal:  Br J Clin Pharmacol       Date:  2018-09-06       Impact factor: 4.335

2.  UPLC-ESI-MS/MS method for the quantitative measurement of aliphatic diamines, trimethylamine N-oxide, and β-methylamino-l-alanine in human urine.

Authors:  Deepak Bhandari; Brett A Bowman; Anish B Patel; David M Chambers; Víctor R De Jesús; Benjamin C Blount
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2018-03-02       Impact factor: 3.205

3.  Targeted metabolomic analysis of plasma metabolites in patients with coronary heart disease in southern China.

Authors:  Zhixiong Zhong; Jing Liu; Qifeng Zhang; Wei Zhong; Bin Li; Cunren Li; Zhidong Liu; Min Yang; Pingsen Zhao
Journal:  Medicine (Baltimore)       Date:  2019-02       Impact factor: 1.817

4.  Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women.

Authors:  Robert Antoni Olek; Joanna Jolanta Samulak; Angelika Katarzyna Sawicka; Dace Hartmane; Solveiga Grinberga; Osvalds Pugovics; Wieslawa Lysiak-Szydlowska
Journal:  Oxid Med Cell Longev       Date:  2019-09-16       Impact factor: 6.543

5.  Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients.

Authors:  Laura Bordoni; Donatella Fedeli; Marco Piangerelli; Iwona Pelikant-Malecka; Adrianna Radulska; Joanna J Samulak; Angelika K Sawicka; Lukasz Lewicki; Leszek Kalinowski; Robert A Olek; Rosita Gabbianelli
Journal:  Biomedicines       Date:  2020-07-23

6.  Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers.

Authors:  Melita Videja; Eduards Sevostjanovs; Sabine Upmale-Engela; Edgars Liepinsh; Ilze Konrade; Maija Dambrova
Journal:  Nutrients       Date:  2022-03-05       Impact factor: 5.717

7.  l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function.

Authors:  Angelika K Sawicka; Dace Hartmane; Patrycja Lipinska; Ewa Wojtowicz; Wieslawa Lysiak-Szydlowska; Robert A Olek
Journal:  Nutrients       Date:  2018-02-23       Impact factor: 5.717

8.  Simultaneous quantification of trimethylamine N-oxide, trimethylamine, choline, betaine, creatinine, and propionyl-, acetyl-, and L-carnitine in clinical and food samples using HILIC-LC-MS.

Authors:  Mohammed E Hefni; Maria Bergström; Torbjörn Lennqvist; Cecilia Fagerström; Cornelia M Witthöft
Journal:  Anal Bioanal Chem       Date:  2021-07-13       Impact factor: 4.142
  8 in total

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