Literature DB >> 25871869

Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions?

Amy G Tsai1, Beatriz Y Salazar Vázquez, Axel Hofmann, Seetharama A Acharya, Marcos Intaglietta.   

Abstract

Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.

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Year:  2015        PMID： 25871869      PMCID： PMC5608479          DOI： 10.1097/NAN.0000000000000103

Source DB:  PubMed          Journal:  J Infus Nurs        ISSN： 1533-1458


  40 in total

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2.  Variability in blood and blood component utilization as assessed by an anesthesia information management system.

Authors:  Steven M Frank; Will J Savage; Jim A Rothschild; Richard J Rivers; Paul M Ness; Sharon L Paul; John A Ulatowski
Journal:  Anesthesiology       Date:  2012-07       Impact factor: 7.892

3.  Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction.

Authors:  Doron Aronson; Eldad J Dann; Lilach Bonstein; Miry Blich; Michael Kapeliovich; Rafael Beyar; Walter Markiewicz; Haim Hammerman
Journal:  Am J Cardiol       Date:  2008-05-09       Impact factor: 2.778

4.  Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide.

Authors:  R J Rohlfs; E Bruner; A Chiu; A Gonzales; M L Gonzales; D Magde; M D Magde; K D Vandegriff; R M Winslow
Journal:  J Biol Chem       Date:  1998-05-15       Impact factor: 5.157

5.  Factors influencing the individual effects of blood transfusions on oxygen delivery and oxygen consumption.

Authors:  M Casutt; B Seifert; T Pasch; E R Schmid; M I Turina; D R Spahn
Journal:  Crit Care Med       Date:  1999-10       Impact factor: 7.598

6.  Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb) as a vasopressor in critically ill patients.

Authors:  G Reah; A R Bodenham; A Mallick; E K Daily; R J Przybelski
Journal:  Crit Care Med       Date:  1997-09       Impact factor: 7.598

7.  PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning.

Authors:  Krishna Sriram; Amy G Tsai; Pedro Cabrales; Fantao Meng; Seetharama A Acharya; Daniel M Tartakovsky; Marcos Intaglietta
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-04-13       Impact factor: 4.733

8.  Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock.

Authors:  Beatriz Y Salazar Vázquez; C Makena Hightower; Judith Martini; Catalina Messmer; Barbara Frienesenecker; Pedro Corbels; Amy G Tsai; Marcos Intaglietta
Journal:  Crit Care Med       Date:  2011-06       Impact factor: 7.598

Review 9.  Economic considerations on transfusion medicine and patient blood management.

Authors:  Axel Hofmann; Sherri Ozawa; Albert Farrugia; Shannon L Farmer; Aryeh Shander
Journal:  Best Pract Res Clin Anaesthesiol       Date:  2013-03

10.  Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective.

Authors:  Judith Martini; Pedro Cabrales; Ananda K; Seetharama A Acharya; Marcos Intaglietta; Amy G Tsai
Journal:  Crit Care       Date:  2008-04-18       Impact factor: 9.097
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  4 in total

1.  A model of anemic tissue perfusion after blood transfusion shows critical role of endothelial response to shear stress stimuli.

Authors:  Weiyu Li; Amy G Tsai; Marcos Intaglietta; Daniel M Tartakovsky
Journal:  J Appl Physiol (1985)       Date:  2021-10-14

Review 2.  Transfusion of Red Blood Cells to Patients with Sepsis.

Authors:  Yi-Ling Chan; Shih-Tsung Han; Chih-Huang Li; Chin-Chieh Wu; Kuan-Fu Chen
Journal:  Int J Mol Sci       Date:  2017-09-11       Impact factor: 5.923

3.  Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock.

Authors:  Wayne B Dyer; Gabriela Simonova; Sara Chiaretti; Mahe Bouquet; Rebecca Wellburn; Silver Heinsar; Carmen Ainola; Karin Wildi; Kei Sato; Samantha Livingstone; Jacky Y Suen; David O Irving; John-Paul Tung; Gianluigi Li Bassi; John F Fraser
Journal:  Intensive Care Med Exp       Date:  2022-04-04

Review 4.  Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes.

Authors:  Carlos Munoz; Federico Aletti; Krianthan Govender; Pedro Cabrales; Erik B Kistler
Journal:  Front Med (Lausanne)       Date:  2020-10-27
  4 in total

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