Literature DB >> 25870659

Polyarthritis and massive small bowel bleed: An unusual combination in scrub typhus.

Nayyar Iqbal1, Solomon Titus2, Aneesh Basheer1, Sanjoy George1, Sanjoy George1, Sudhagar Mookkappan1, Shashikala Nair3, Thomas Alexander4, Anita Ramdas5, Sivakumar Periyasamy1, Patricia Anitha3, Reba Kanungo3.   

Abstract

Scrub typhus is an acute febrile illness caused by the intracellular parasite Orientia tsutsugamushi. Although most cases present with mild symptoms and signs and recover spontaneously, some cases can be severe with multi-organ dysfunction and a protracted course, which may be fatal if left untreated. Apart from fever and constitutional symptoms, atypical presentations allow this disease to mimic several common conditions. We report a case of scrub typhus in an 18-year-old male who presented with severe polyarthritis involving all large joints and a massive lower gastrointestinal bleed from ulcers in the terminal ileum, secondary to vasculitis in the small bowel. This combination of pathologies has not previously been reported in cases of scrub typhus. The patient improved following surgical intervention and specific anti-rickettsial therapy with azithromycin.

Entities:  

Keywords:  Scrub typhus; polyarthritis; small bowel bleed

Year:  2015        PMID: 25870659      PMCID: PMC4385814          DOI: 10.4066/AMJ.2015.2299

Source DB:  PubMed          Journal:  Australas Med J        ISSN: 1836-1935


  25 in total

1.  Serological evidence for the continued presence of human rickettsioses in southern India.

Authors:  E Mathai; G Lloyd; T Cherian; O C Abraham; A M Cherian
Journal:  Ann Trop Med Parasitol       Date:  2001-06

2.  Leptospirosis in Malaya. I. Sporadic cases among military and civilian personnel.

Authors:  F R MCCRUMB; J L STOCKARD; C R ROBINSON; L H TURNER; D G LEVIS; C W MAISEY; M F KELLEHER; C A GLEISER; J E SMADEL
Journal:  Am J Trop Med Hyg       Date:  1957-03       Impact factor: 2.345

3.  Gastro-intestinal bleeding in scrub typhus.

Authors:  Sanjay K Mahajan
Journal:  J Assoc Physicians India       Date:  2011-09

4.  Outbreak of scrub typhus in Pondicherry.

Authors:  M Vivekanandan; Anna Mani; Yamini Sundara Priya; Ajai Pratap Singh; Samuel Jayakumar; Shashikala Purty
Journal:  J Assoc Physicians India       Date:  2010-01

5.  Scrub typhus: prevalence and diagnostic issues in rural Southern India.

Authors:  Rita Isaac; George M Varghese; Elizabeth Mathai; Manjula J; Inbakumar Joseph
Journal:  Clin Infect Dis       Date:  2004-11-01       Impact factor: 9.079

Review 6.  Spotted fevers & typhus fever in Tamil Nadu.

Authors:  H V Batra
Journal:  Indian J Med Res       Date:  2007-08       Impact factor: 2.375

7.  Scrub typhus after a trip to Vietnam.

Authors:  M M Thiebaut; F Bricaire; D Raoult
Journal:  N Engl J Med       Date:  1997-05-29       Impact factor: 91.245

8.  Association of high Orientia tsutsugamushi DNA loads with disease of greater severity in adults with scrub typhus.

Authors:  Piengchan Sonthayanon; Wirongrong Chierakul; Vanaporn Wuthiekanun; Kriangsak Phimda; Sasithon Pukrittayakamee; Nicholas P Day; Sharon J Peacock
Journal:  J Clin Microbiol       Date:  2008-12-17       Impact factor: 5.948

9.  Evaluation of nested PCR for the diagnosis of scrub typhus among patients with acute pyrexia of unknown origin.

Authors:  Watcharee Saisongkorh; Mongkol Chenchittikul; Khachornsakdi Silpapojakul
Journal:  Trans R Soc Trop Med Hyg       Date:  2004-06       Impact factor: 2.184

10.  Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa.

Authors:  Kedareshwar P S Narvencar; Savio Rodrigues; Ramnath P Nevrekar; Lydia Dias; Amit Dias; Marina Vaz; E Gomes
Journal:  Indian J Med Res       Date:  2012-12       Impact factor: 2.375

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